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首页> 外文期刊>Journal of dermatological science >A nucleic acid-based medication for allergic skin diseases
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A nucleic acid-based medication for allergic skin diseases

机译：一种用于过敏性皮肤疾病的基于核酸的药物

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Among allergic skin diseases, atopic dermatitis is the most difficult to cure. In the majority of patients, atopic dermatitis can be easily controlled by treatment based on three therapeutic approaches: avoidance of precipitating factors, skin care, and medication. In some adult patients, however, severe atopic dermatitis is refractory to treatment, and no fundamental effective treatment modality has yet been established for such cases. Chronic contact dermatitis without an identified causative hapten is also considered an allergic skin disease that is difficult to cure. Topical nucleic acid-based medications are currently being applied clinically, and an ointment containing nuclear factor-κB decoy oligodeoxynucleotides (hereafter referred to as Decoy) has reached clinical trials. In addition, synthetic double-stranded DNA with high affinity for signal transducers and activators of transcription 6 (STAT6) introduced in vivo as a decoy cis element to bind the transcriptional factor and block the activated gene that contributes to the onset and progression of atopic dermatitis functions as an effective therapeutic agent. We also introduce another STAT1 decoy treatment, cytosine-phosphate-guanine-ODN or STAT6 small interfering RNA therapy, for allergic skin diseases.
机译：在过敏性皮肤病中，特应性皮炎是最难治愈的。在大多数患者中，异位性皮炎可以通过基于三种治疗方法的治疗来轻松控制：避免沉淀因子，皮肤护理和药物治疗。然而，在一些成年患者中，严重的特应性皮炎难以治疗，并且尚未建立针对这种情况的基本有效治疗方式。没有确定致病性半抗原的慢性接触性皮炎也被认为是难以治愈的过敏性皮肤病。目前，临床上正在使用基于局部核酸的药物，并且含有核因子-κB诱饵寡脱氧核苷酸（以下称为诱饵）的药膏已进入临床试验。另外，对体内的信号转导子和转录激活子6（STAT6）具有高亲和力的合成双链DNA作为诱饵顺式元件引入体内，以结合转录因子并阻断活化的基因，从而促进特应性皮炎的发生和发展。作为有效的治疗剂。我们还针对过敏性皮肤病引入了另一种STAT1诱饵治疗方法：胞嘧啶-磷酸-鸟嘌呤-ODN或STAT6小干扰RNA治疗。

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