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首页> 外文期刊>Journal of dermatological science >MicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis
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MicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis

机译：MicroRNA-223和miR-143是牛皮癣疾病活动的重要系统生物标志物

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Background: Psoriasis is a systemic inflammatory skin disease. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that recently have been found in the blood to be relevant as disease biomarkers. Objective: We aimed to explore miRNAs potential as blood biomarkers for psoriasis. Methods: Using microarray and quantitative real-time PCR we measured the global miRNA expression in whole blood, plasma and peripheral blood mononuclear cells (PBMCs) from patients with psoriasis and healthy controls. Results: We identified several deregulated miRNAs in the blood from patients with psoriasis including miR-223 and miR-143 which were found to be significantly upregulated in the PBMCs from patients with psoriasis compared with healthy controls (FCH. =. 1.63, P<. 0.01; FCH. =. 2.18, P<. 0.01, respectively). In addition, miR-223 and miR-143 significantly correlated with the PASI. score (r=. 0.46, P<. 0.05; r=. 0.55, P<. 0.02, respectively). Receiver-operating characteristic analysis (ROC) showed that miR-223 and -143 have the potential to distinguish between psoriasis and healthy controls (miR-223: area under the curve (AUC). =. 0.80, miR-143: AUC. =. 0.75). Interestingly, after 3-5 weeks of treatment with methotrexate following a significant decrease in psoriasis severity, miR-223 and miR-143 were significantly downregulated in the PBMCs from patients with psoriasis. Conclusion: We suggest that changes in the miR-223 and miR-143 expressions in PBMCs from patients with psoriasis may serve as novel biomarkers for disease activity in psoriasis; however, further investigations are warranted to clarify their specific roles.
机译：背景：牛皮癣是一种全身性炎症性皮肤病。微小RNA（miRNA）是一类小的非编码RNA分子，最近在血液中被发现与疾病生物标记有关。目的：我们旨在探索miRNA作为牛皮癣血液生物标记物的潜力。方法：使用微阵列和定量实时PCR，我们测量了牛皮癣患者和健康对照者的全血，血浆和外周血单核细胞（PBMC）中的整体miRNA表达。结果：我们鉴定了牛皮癣患者血液中的几种miRNA失控，包括miR-223和miR-143，发现与健康对照相比，牛皮癣患者PBMC中的miRNA显着上调（FCH。= 1.63，P <。 0.01; FCH。= 2.18，P <。0.01）。另外，miR-223和miR-143与PASI显着相关。得分（r = .0.46，P <.0.05; r = .0.55，P <.0.02）。接受者操作特征分析（ROC）显示，miR-223和-143有潜力区分牛皮癣和健康对照（miR-223：曲线下面积（AUC）= 0.80，miR-143：AUC = 0.75）。有趣的是，牛皮癣严重程度显着降低后，用甲氨蝶呤治疗3-5周后，牛皮癣患者的PBMC中miR-223和miR-143明显下调。结论：我们建议银屑病患者PBMCs中miR-223和miR-143表达的变化可能是牛皮癣疾病活动的新生物标记。但是，有必要进行进一步调查以阐明其具体作用。

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