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首页> 外文期刊>Journal of dermatological science >Anti-graying effect of the extract of Pueraria thunbergiana via upregulation of cAMP/MITF-M signaling pathway
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Anti-graying effect of the extract of Pueraria thunbergiana via upregulation of cAMP/MITF-M signaling pathway

机译：葛根提取物通过上调cAMP / MITF-M信号通路的抗草甘膦作用

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摘要

Hair graying is one of the typical signs of human aging, and the maintenance of hair pigmentation is dependent on the presence and functionality of follicular melanocytes [1]. In this study, the extract of Pueraria thunbergiana (PT extract) and its active compound, puerarin, were investigated for their stimulation of melanogenesis via the cAMP/MITF-M signaling pathway in vitro, and for their prevention of follicular depigmentation in a hair cycle-accelerated hair graying mouse model. Puerarin (7,4'-dihydroxyisoflavone-8beta-glucopyranoside) is a major active ingredient of P. thunbergiana radix which has the known therapeutic effects on hypertension, cerebral ischemia, myocardial ischemia, diabetes mellitus and arteriosclerosis. The molecular mechanism of puerarin is believed to involve the scavenging of reactive oxygen species [2].
机译：头发变白是人类衰老的典型标志之一，头发色素沉着的维持取决于卵泡黑素细胞的存在和功能[1]。在这项研究中，研究了葛根提取物（PT提取物）及其活性化合物葛根素在体外通过cAMP / MITF-M信号通路刺激黑素生成，以及在毛发周期中预防毛囊色素沉着的现象。 -加速的头发变白小鼠模型。葛根素（7,4'-二羟基异黄酮-8β-吡喃葡萄糖苷）是紫苏的主要活性成分，对高血压，脑缺血，心肌缺血，糖尿病和动脉硬化具有已知的治疗作用。葛根素的分子机制被认为与活性氧的清除有关[2]。

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