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首页> 外文期刊>Journal of dermatological science >Polymorphisms in genes involved in oxidative stress and their interactions with lifestyle factors on skin cancer risk.
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Polymorphisms in genes involved in oxidative stress and their interactions with lifestyle factors on skin cancer risk.

机译:与氧化应激有关的基因多态性及其与生活方式因素的相互作用对皮肤癌的风险。

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摘要

Ultraviolet (UV)-induced oxidative stress has been implicated in skin carcinogenesis [1]. Several antioxidant enzymes, such as glutathione peroxidase (GPX) and catalase (CAT), counteract oxidative damage and constitute a primary defense against oxidative stress. GPX is a soluble selenoprotein that reduces H_2O_2 and organic hydroperoxides to H_2O, and GPX1 is the most abundant and ubiquitous intracellular isoform [1 ]. GPX1 activity is not strongly affected by UV and is considered to be the most important antioxidant enzyme defense mechanism in the skin [2]. CAT is a heme enzyme that neutralizes reactive oxygen species by converting H_2O_2 to H_2O and O_2. CAT activity in the skin is significantly reduced after exposure to UV [2], which suggests its effect may be prone to effect modification by environmental factors.
机译:紫外线(UV)诱导的氧化应激与皮肤致癌作用有关[1]。几种抗氧化酶,例如谷胱甘肽过氧化物酶(GPX)和过氧化氢酶(CAT),可抵消氧化损伤,并构成抵抗氧化应激的主要防御手段。 GPX是一种可溶的硒蛋白,可将H_2O_2和有机氢过氧化物还原为H_2O,GPX1是最丰富和普遍存在的细胞内同工型[1]。 GPX1的活性不受紫外线的强烈影响,被认为是皮肤中最重要的抗氧化酶防御机制[2]。 CAT是一种血红素酶,通过将H_2O_2转化为H_2O和O_2来中和活性氧。暴露于紫外线后,皮肤中的CAT活性显着降低[2],这表明其作用可能容易受到环境因素的影响。

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