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首页> 外文期刊>Journal of dermatological science >The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides.
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The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides.

机译：低血糖负荷饮食对寻常痤疮和皮肤表面甘油三酸酯脂肪酸组成的影响。

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BACKGROUND: Dietary factors have long been implicated in acne pathogenesis. It has recently been hypothesized that low glycemic load diets may influence sebum production based on the beneficial endocrine effects of these diets. OBJECTIVE: To determine the effect of a low glycemic load diet on acne and the fatty acid composition of skin surface triglycerides. METHODS: Thirty-one male acne patients (aged 15-25 years) completed sebum sampling tests as part of a larger 12-week, parallel design dietary intervention trial. The experimental treatment was a low glycemic load diet, comprised of 25% energy from protein and 45% from low glycemic index carbohydrates. In contrast, the control situation emphasized carbohydrate-dense foods without reference to the glycemic index. Acne lesion counts were assessed during monthly visits. At baseline and 12-weeks, the follicular sebum outflow and composition of skin surface triglycerides were assessed using lipid absorbent tapes. RESULTS: At 12 weeks, subjects on the experimental diet demonstrated increases in the ratio of saturated to monounsaturated fatty acids of skin surface triglycerides when compared to controls [5.3+/-2.0% (mean+/-S.E.M.) vs. -2.7+/-1.7%, P=0.007]. The increase in the saturated/monounsaturated ratio correlated with acne lesion counts(r=-0.39, P=0.03). Increased follicular sebum outflow was also associated with an increase in the proportion of monounsaturated fatty acids in sebum (r=0.49, P=0.006). CONCLUSION: This suggests a possible role of desaturase enzymes in sebaceous lipogenesis and the clinical manifestation of acne. However, further work is needed to clarify the underlying role of diet in sebum gland physiology.
机译：背景：饮食因素长期以来与痤疮发病有关。最近有假设认为，低血糖负荷饮食可能会基于这些饮食的有益内分泌作用而影响皮脂的产生。目的：确定低血糖饮食对痤疮和皮肤表面甘油三酸酯脂肪酸组成的影响。方法：作为一项为期12周的平行设计饮食干预试验的一部分，共有31名男性痤疮患者（年龄15-25岁）完成了皮脂采样测试。实验治疗是低血糖负荷饮食，包括25％的蛋白质能量和45％的低血糖指数碳水化合物。相比之下，对照情况强调的是碳水化合物密集型食品，而未参考血糖指数。每月访问期间评估痤疮病变计数。在基线和第12周，使用脂质吸收带评估卵泡皮脂流出和皮肤表面甘油三酸酯的成分。结果：在第12周时，与对照组相比，实验饮食的受试者表现出皮肤表面甘油三酸酯的饱和脂肪酸与单不饱和脂肪酸之比增加[5.3 +/- 2.0％（平均值+/- SEM）与-2.7 +/- 1.7％，P = 0.007]。饱和/单不饱和比的增加与痤疮病变数相关（r = -0.39，P = 0.03）。卵泡皮脂流出增加也与皮脂中单不饱和脂肪酸比例增加有关（r = 0.49，P = 0.006）。结论：这表明去饱和酶可能在皮脂生成和痤疮的临床表现中发挥作用。然而，需要进一步的工作来阐明饮食在皮脂腺生理中的潜在作用。

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