...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of dermatological science >Secreted aspartic proteinase from Candida albicans acts as a chemoattractant for peripheral neutrophils
【24h】

Secreted aspartic proteinase from Candida albicans acts as a chemoattractant for peripheral neutrophils

机译：白色念珠菌分泌的天冬氨酸蛋白酶可作为外周嗜中性粒细胞的趋化因子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Candida albicans is one of the fungal species chiefly responsible for cases of superficial and systemic candidiasis [1 ]. We previously demonstrated that C. albicans was able to produce a secreted aspartic proteinase when the cells were cultivated in a medium containing human stratum corneum as a nitrogen source [2-4]. Secreted aspartic proteinases (SAPs) from C. albicans are encoded by a family of 10 SAP genes [5]. SAP 1-3 are expressed in the yeast forms; SAP 4-6 in the hypal forms; SAP 7 in a mouse model of intravenous infection; and SAP 8 transiently in yeast and epithelial models. SAP 9 and 10 encode glycosylphosphatidylinositol (GPI)-anchoring domains [6]. Among these, SAP 2 is the most abundantly secreted protein in vitro when the organism is grown in the presence of protein as the sole source of nitrogen [7]. In this study, we examined whether SAP from C albicans has a chemotactic activity for neutrophils which would induce the host's reaction to candidiasis.
机译：白色念珠菌是真菌种类之一，主要负责浅表性和全身性念珠菌病[1]。我们先前证明，当在含有人角质层作为氮源的培养基中培养细胞时，白色念珠菌能够产生分泌的天冬氨酸蛋白酶[2-4]。白色念珠菌分泌的天冬氨酸蛋白酶（SAPs）由10个SAP基因家族编码[5]。 SAP 1-3以酵母形式表达; SAP 4-6的hypal形式; SAP 7在小鼠静脉感染模型中;和SAP 8在酵母和上皮模型中短暂出现。 SAP 9和10编码糖基磷脂酰肌醇（GPI）锚定域[6]。其中，当有机体在蛋白质作为唯一氮源的情况下生长时，SAP 2是体外分泌最丰富的蛋白质[7]。在这项研究中，我们检查了来自白色念珠菌的SAP是否对嗜中性粒细胞具有趋化活性，从而诱导宿主对念珠菌病的反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号