A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols

Ito Shosuke; Wakamatsu Kazumasa

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A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols

机译：区分酚性皮肤增白酪氨酸酶抑制剂和白细胞诱导酚的简便筛选方法

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Background: Tyrosinase is able to oxidize a great number of phenols and catechols to form ortho-quinones. Ortho-quinones are highly reactive compounds that exert cytotoxicity through binding with thiol enzymes and the production of reactive oxygen species. Certain phenolic (and catecholic) compounds are known to induce contact/occupational leukoderma through activation to ortho-quinones.

机译：背景：酪氨酸酶能够氧化大量的酚和儿茶酚以形成邻醌。邻醌是高反应性化合物，通过与硫醇酶结合并产生活性氧而发挥细胞毒性作用。已知某些酚类（和儿茶酚）化合物可通过活化邻醌来诱导接触/职业性白皮病。

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《Journal of dermatological science》 |2015年第1期|共7页
作者
Ito Shosuke; Wakamatsu Kazumasa;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
Melanocyte toxicity; Rhododendrol; Tyrosinase; Tyrosinase inhibitor; Whitening agent;

机译：黑素细胞毒性;杜鹃花;酪氨酸酶;酪氨酸酶抑制剂;增白剂;

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1. A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols [J] . Ito Shosuke, Wakamatsu Kazumasa Journal of dermatological science . 2015,第1期

机译：区分酚性皮肤增白酪氨酸酶抑制剂和白细胞诱导酚的简便筛选方法
2. Tyrosinase immobilized magnetic nanobeads for the amperometric assay of enzyme inhibitors: Application to the skin whitening agents [J] . Sima V.H., Patris S., Aydogmus Z., Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2011,第3期

机译：酪氨酸酶固定的磁性纳米珠用于酶抑制剂的安培分析：在皮肤增白剂中的应用
3. Simplified Method for the Screening of Technological Maturity of Red Grape and Total Phenolic Compounds of Red Grape Skin: Application of the Characteristic Vector Method to Near-Infrared Spectra [J] . Nogales-Bueno Julio, Ayala Fernando, Miguel Hernandez-Hierro Jose, Journal of Agricultural and Food Chemistry . 2015,第17期

机译：筛选红葡萄技术成熟度和红葡萄皮中总酚类化合物的简化方法：特征向量法在近红外光谱中的应用
4. Application of a FIA System Using an Immobilized Tyrosinase to Screening of Tyrosinase Inhibitors from Herbal Medicines [C] . Shin-va Ohki, Kana Kano, Yuko Sakurai, East Asia Conference on Chemical Sensors . 2005

机译：使用固定化酪氨酸酶应用FIA系统从草药中筛选酪氨酸酶抑制剂的应用
5. I. Oxidation-Initiated Nazarov Cyclization of Vinyl Alkoxyallenes. II. Efforts Toward an Improved Synthesis of Rocaglamide Amenable to Analog Synthesis. III. A Convenient Cycloaromatization Protocol for Synthesis of Polysubstituted Phenol Derivatives: Method Development and Mechanistic Studies [D] . Spencer, William T., III 2013

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6. CONVENIENT METHOD OF PROCEDURE FOR HYGIENIC LABORATORY PHENOL CO-EFFICIENT METHOD [O] . E. B. Phelps, H. D. Pease, J. F. Anderson, 1912

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7. Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances [O] . Lucia Panzella, Alessandra Napolitano 2019

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A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols

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