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首页> 外文期刊>Clinical toxicology: the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists >Tongue angioedema in vivo: antagonist response of anti-inflammatory drugs.
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Tongue angioedema in vivo: antagonist response of anti-inflammatory drugs.

机译：体内舌部血管性水肿：抗炎药的拮抗剂反应。

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INTRODUCTION: The toxicity of Dieffenbachia picta, an ornamental plant, arises from its ability to cause painful edema of oral mucous membranes, buccal ulcerations, and tongue hypertrophy after chewing on the stem or contact with the sap. OBJECTIVES: We compared the anti-inflammatory effect of eugenol (2-methoxy-4-(2-propenyl)phenol) to different drugs, and investigated the role of oxalate crystals in the development of the inflammation reaction. METHODS: Tongue edema in live mice were measured with a digital tachymeter, 2 h after topical application (0.1 mL) or tissue injection (0.05 mL) of D. picta sap. The mice were treated by intraperitoneal or topical application of drugs, 15 min after edema induction. Vascular permeability was quantified based on abdominal skin plasma extravasation of Evans blue dye in response to intradermal administration of D. picta sap. The proteolytic assay was carried out as previously described (Kunitz M. Crystalline soybean trypsin inhibitor. General properties. J Gen Physiol 1947; 30:291-310.). RESULTS: Arachidonate cascade antagonists and eugenol showed anti-edematogenic effects. High doses of eugenol (50 mug/kg) and sodium cromoglycate (100 mg/kg), but not a combination of the two, inhibited plasma extravasations. The sap without crystals, its methanol extract, or the ethanol-washed crystals in saline-reconstituted solution did not reproduce the tongue edema seen with the original sap. Topical application of 10% sodium bicarbonate completely abolished the tongue edema. CONCLUSIONS: The inflammatory response induced by D. picta may be due to mechanical tissue damage resulting from the physical presence of calcium oxalate crystals. We were, however, unable to exclude the possibility of an insoluble toxicity present within the sap as an etiological agent. We realized that emergency treatment should also aim to inhibit antidromic vasodilation and axon reflex flare, reducing mastocyte degranulation and release of tachykinins from nerve endings. We speculate that eugenol showed better antiedematogenic results because it seems to function not only as a classic non-steroidal anti-inflammatory drug, but also as a local anesthetic, blocking neurotransmission in the damaged tissue.
机译：简介：百叶草属植物，是一种观赏植物，其毒性源于其咀嚼茎或与树液接触后引起口腔粘膜疼痛性水肿，颊溃疡和舌头肥大的能力。目的：我们比较了丁子香酚（2-甲氧基-4-（2-丙烯基）苯酚）与不同药物的抗炎作用，并研究了草酸盐晶体在炎症反应发展中的作用。方法：用数字速测仪，在局部应用皮下皮液（0.1mL）或组织注射（0.05mL）2小时后，用数字式测速仪测量舌头水肿。在水肿诱导后15分钟通过腹膜内或局部施用药物治疗小鼠。血管通透性是根据伊万斯蓝染料在皮下注射皮液后的腹部皮肤血浆外渗来定量的。如前所述进行蛋白水解测定（Kunitz M.Crystalline大豆胰蛋白酶抑制剂。一般性质，J Gen Physiol 1947; 30：291-310）。结果：花生四烯酸级联拮抗剂和丁子香酚具有抗水肿作用。高剂量的丁子香酚（50杯/千克）和色甘酸钠（100毫克/千克），但不能两者结合使用，可抑制血浆外渗。没有晶体的汁液，其甲醇提取物或在盐水配制的溶液中用乙醇洗涤的晶体不能重现原始树液所见的舌头水肿。局部应用10％碳酸氢钠可完全消除舌头水肿。结论D. picta诱导的炎症反应可能是由于草酸钙晶体物理存在导致的机械组织损伤。然而，我们无法排除作为病原体的汁液中存在不溶性毒性的可能性。我们意识到，紧急治疗还应旨在抑制抗皮肤血管扩张和轴突反射性耀斑，减少肥大细胞脱粒和从神经末梢释放速激肽。我们推测丁子香酚显示出更好的抗水肿作用，因为丁香酚似乎不仅起经典的非甾体类抗炎药的作用，而且还作为局部麻醉剂起作用，阻断受损组织的神经传递。

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