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首页> 外文期刊>Journal of dermatological science >High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas.
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High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas.

机译：Dicer的高表达揭示了在某些原发性皮肤T细胞淋巴瘤亚型中的不良预后影响。

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BACKGROUND: Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE: We initiated a retrospective study to characterize the alterations in the expression profile of Dicer in patients with primary cutaneous T cell lymphomas (CTCL). METHODS: A total of 50 consecutive patients with primary CTCL were studied, with the majority having mycosis fungoides (n=34). Five patients had primary cutaneous CD 30+ anaplastic large cell lymphoma, four patients each had lymphomatoid papulosis and primary cutaneous CD4-positive small/medium T-cell lymphoma, one primary cutaneous gammadelta T cell lymphoma, one Sezary syndrome and another subcutaneous panniculitis-like T cell lymphoma of alphabeta-phenotype. Immunohistochemistry was performed on paraffin sections using a commercially available antibody against Dicer. Intensity of expression was correlated with clinical parameters including disease specific survival (DSS) and time to progression (TTP). RESULTS: After a median follow-up of 74 months (range: 1-271), 12/50 patients (24%) have died. Univariate and multivariate analysis for disease-specific survival showed Dicer expression and stage as a negative predictive factor in the sole group of MF patients (n=34) as well as in the heterogeneous group of patients (n=50), but not gender, histological subtype, primary localization of disease, age and recurrence of lymphoma (p>0.05). CONCLUSION: Our data suggest Dicer expression as a possible molecular marker in patients with MF and apparently indicate that miRNA(s) might be of clinical relevance in CTCL.
机译：背景：microRNA（miRNA）的异常表达与多种肿瘤和原发性皮肤T细胞淋巴瘤的发生有关。 Dicer，一种类似于核糖核酸酶的酶，对于miRNA加工至关重要。目的：我们进行了一项回顾性研究，以描述原发性皮肤T细胞淋巴瘤（CTCL）患者Dicer表达谱的变化。方法：总共研究了50例连续的原发性CTCL患者，其中大多数患有真菌病真菌病（n = 34）。 5例原发性皮肤CD 30+间变性大细胞淋巴瘤，4例各有淋巴瘤样丘疹病和原发性皮肤CD4阳性小/中T细胞淋巴瘤，1例原发性皮肤γT细胞淋巴瘤，一种Sezary综合征和另一种皮下脂膜炎表型的T细胞淋巴瘤。使用市售的针对Dicer的抗体对石蜡切片进行免疫组织化学。表达强度与临床参数相关，包括疾病特异性存活率（DSS）和进展时间（TTP）。结果：在中位随访74个月（范围：1-271）后，有12/50例患者（24％）死亡。对疾病特异性存活率的单因素和多因素分析显示，在唯一的MF患者组（n = 34）和异质性患者组（n = 50）中，Dicer表达和分期是阴性的预测因素，但对于性别，组织学亚型，疾病的主要部位，年龄和淋巴瘤复发（p> 0.05）。结论：我们的数据表明Dicer表达可能是MF患者的一种可能的分子标志物，并且显然表明miRNA在CTCL中可能具有临床意义。

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