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首页> 外文期刊>Journal of dermatological science >Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kappaB activation.
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Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kappaB activation.

机译：Elafin和分泌型白细胞蛋白酶抑制剂通过MAPK / ERK和NF-κB激活刺激人角质形成细胞产生细胞因子和趋化因子。

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摘要

The skin has evolved an innate chemical defense system composed of antimicrobial peptides (AMPs), which provide a rapid, direct front-line component of innate immunity [1 ]. In addition to their antimicrobial properties, AMPs exhibit a variety of immuno-modulatory activities in keratinocytes [1]. Besides the enhancement of cytokine/chemokine production, the multiple functions of AMPs in keratinocytes include chemotaxis, cell proliferation and wound healing [1]. Elafin (skin-derived antileukoprotease, SKALP) and secretory leukocyte protease inhibitor (SLPI) belong to the antileukoproteinase superfamily of proteinase inhibitors [1,2]. These proteins have been detected in keratinocytes, and their expression is increased in inflamed and/or infected skin and during wound healing [1,2]. Both elafin/SKALP and SLPI exhibit antimicrobial activities against various pathogens [1-4].
机译：皮肤已经进化出一种由抗菌肽（AMPs）组成的先天化学防御系统，该系统可提供先天免疫的快速，直接的一线成分[1]。除其抗菌特性外，AMP在角质形成细胞中还表现出多种免疫调节活性[1]。除了增强细胞因子/趋化因子的产生，角质形成细胞中AMPs的多种功能还包括趋化性，细胞增殖和伤口愈合[1]。 Elafin（皮肤抗白蛋白蛋白酶，SKALP）和分泌型白细胞蛋白酶抑制剂（SLPI）属于蛋白酶抑制剂的抗白蛋白超家族[1,2]。这些蛋白质已经在角质形成细胞中被检测到，并且在发炎和/或感染的皮肤以及伤口愈合期间它们的表达增加了[1,2]。 elafin / SKALP和SLPI均显示出对各种病原体的抗菌活性[1-4]。

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