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首页> 外文期刊>Journal of dermatological science >Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.
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Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.

机译：MHC，LCE和IL12B的变异对中国人群的牛皮癣风险具有上位性作用。

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BACKGROUND: Psoriasis has long been considered as a complex disease, and gene-gene or gene-environment interactions may jointly influence the etiology for psoriasis. OBJECTIVE: We evaluated the associations of single nucleotide polymorphisms (SNPs) in MHC region, and determined the epistasis and combined effects of MHC locus and IL12B, LCE on risk for psoriasis. METHODS: We genotyped SNP rs1265181 (MHC) in 5067 cases and 6404 controls, combining with the prior GWAS data (1139 cases and 1132 controls), we explored the genetic interaction among MHC locus, LCE and IL12B by using logistic regression analysis. We evaluated the combined effects of MHC locus and two non-MHC loci in the combined sample of 6206 cases and 7536 controls. RESULTS: Extremely high significance of association was detected between rs1265181 and psoriasis (p combined < 10E--300, OR = 16.52, 95% CI: 15.28-18.44). We observed significant interactions between MHC and LCE (p = 0.0016) and between MHC and IL12B (p = 0.0036). The risk increased some 26-fold in individuals with risk alleles in both MHC and LCE as compared with those without risk alleles, and individual carrying risk alleles of MHC and IL12B has around 36-fold higher risk of psoriasis than those with protective alleles. CONCLUSIONS: This study provides evidence for the epistatic effects between MHC locus and LCE, IL12B genes. Besides, we suggest that MHC might be the main effect gene on the risk for psoriasis. This data may contribute to our understanding of psoriasis genetic interactions and account for the additional risk of certain patients to develop psoriasis.
机译：背景：牛皮癣长期以来被认为是一种复杂的疾病，基因-基因或基因-环境相互作用可能共同影响牛皮癣的病因。目的：我们评估了MHC区域中单核苷酸多态性（SNPs）的关联，并确定了MHC基因座和IL12B，LCE对银屑病风险的上皮性和联合作用。方法：我们对5067例SNP rs1265181（MHC）和6404个对照进行基因分型，并结合先前的GWAS数据（1139例和1132个对照），通过逻辑回归分析探讨了MHC基因座，LCE和IL12B之间的遗传相互作用。我们在6206例病例和7536例对照样本中评估了MHC基因座和两个非MHC基因座的综合作用。结果：rs1265181与牛皮癣之间的关联具有极高的意义（p合并<10E--300，OR = 16.52，95％CI：15.28-18.44）。我们观察到MHC和LCE之间（p = 0.0016）以及MHC和IL12B之间（p = 0.0036）有显着的相互作用。与没有风险等位基因的人相比，在MHC和LCE中都有风险等位基因的人的风险增加了约26倍，并且携带MHC和IL12B风险等位基因的人的银屑病风险比具有保护性等位基因的人高36倍。结论：本研究为MHC基因座与LCE，IL12B基因之间的上位性作用提供了证据。此外，我们建议MHC可能是牛皮癣风险的主要影响基因。这些数据可能有助于我们对牛皮癣遗传相互作用的理解，并说明某些患者发生牛皮癣的额外风险。

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