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首页> 外文期刊>Journal of dermatological science >Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic dermatitis.
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Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic dermatitis.

机译：循环性Th17细胞减少与特应性皮炎中CCL17，IgE和嗜酸性粒细胞水平升高有关。

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BACKGROUND: Clinical significance of circulating CD4(+) T cell subsets, including T-helper (Th)1, Th2, Th17 and regulatory T (Treg) cells, in patients with atopic dermatitis (AD) remains unclear. No previous studies have simultaneously evaluated the four T cell subset profiles in AD. OBJECTIVE: The aim of the present study was to explore whether the percentage of these four subsets of CD4(+) T cells correlate to the severity parameters of AD patients. METHODS: Intracellular expression of interferon (IFN)-gamma, interleukin (IL)-4, IL-17 and forkhead box P3 (Foxp3) in CD4(+) T cells was evaluated in peripheral blood mononuclear cells from normal controls and patient with AD as well as with chronic eczema using a flow cytometer. Serum CCL17 levels were measured as an objective severity parameter of AD together with percentage of eosinophils and serum IgE levels. RESULTS: In AD patients, the number of Th1 (IFN-gamma(+)) and Th17 (IL-17(+)) subsets was significantly decreased, but that of Th2 (IL-4(+)) and Treg (Foxp3(+)) subsets was similar to that of normal controls. The T cell subset profiles of patients with chronic eczema were not different with those of normal controls. The frequency of Th17cells, particularly that of the IFN-gamma(nega)IL-17(+) subset, showed a significant negative correlation with CCL17, IgE and eosinophil levels in AD patients. This was, however, not the case in Th1, Th2 and Treg cells. CONCLUSION: Decreased circulating Th17 cells might contribute to activity of AD.
机译：背景：特应性皮炎（AD）患者中循环CD4（+）T细胞亚群的临床意义尚不清楚，包括T-helper（Th）1，Th2，Th17和调节性T（Treg）细胞。以前没有研究同时评估AD中的四个T细胞亚群分布。目的：本研究的目的是探讨这四个CD4（+）T细胞亚群的百分比是否与AD患者的严重程度参数相关。方法：评估正常对照和AD患者外周血单个核细胞中CD4（+）T细胞中干扰素（IFN）-γ，白介素（IL）-4，IL-17和叉头盒P3（Foxp3）的细胞内表达。以及使用流式细胞仪的慢性湿疹。血清CCL17水平作为AD的客观严重程度参数以及嗜酸性粒细胞百分比和血清IgE水平进行了测量。结果：在AD患者中，Th1（IFN-γ（+））和Th17（IL-17（+））亚群的数量显着减少，而Th2（IL-4（+））和Treg（Foxp3（ +））子集与正常对照相似。慢性湿疹患者的T细胞亚群特征与正常对照组无差异。 Th17细胞的频率，特别是IFN-γ（nega）IL-17（+）亚群的频率，与AD患者的CCL17，IgE和嗜酸性粒细胞水平呈显着负相关。然而，在Th1，Th2和Treg细胞中却并非如此。结论：循环Th17细胞减少可能有助于AD的活性。

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