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首页> 外文期刊>Journal of dermatological science >Epidermogenesis in a skin wound deep through the basement membrane contributes to scar formation
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Epidermogenesis in a skin wound deep through the basement membrane contributes to scar formation

机译：穿过基膜深处的皮肤表皮生成助长疤痕形成

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This MiniReview is a personal recollection of selected research topics, which the author in collaboration with colleagues has studied, aiming to improve the predictability of drug therapy. In early studies, we found bi- and trivalent cations to reduce the absorption of various tetracyclines and fluoroquinolones. Certain antacids elevated the bioavailability of some non-steroidal anti-inflammatory drugs and sulphonylureas. Various brands of phenytoin tablets revealed great differences in their bioavailability, causing clinical consequences. Numerous factors affecting the antidotal effect of activated charcoal were also studied, with charcoal compared to other gastrointestinal decontamination methods, including ipecac and gastric lavage. Effect of age and diseases on the pharmacokinetics of drugs was a research topic. Acute sotalol intoxications revealed its QT-prolonging properties, and even small mixed overdoses of moclobemide with serotonergic drugs proved fatal. Itraconazole and other potent inhibitors of CYP3A4 could drastically increase exposure to drugs like midazolam, triazolam, buspirone, lovastatin, simvastatin and oxycodone, whereas rifampicin greatly reduced their plasma concentrations. A change from potent inhibition to induction caused a 400-fold change in the exposure to oral midazolam. CYP2C8 was revealed to be crucial in the metabolism and interactions of several drugs. Many interactions affecting statins are CYP3A4-mediated, but transporters are important in certain interactions. Tizanidine is very susceptible to CYP1A2 inhibition. Fruit juices such as grapefruit juice can raise or lower exposure to different drugs. Both drug interactions and pharmacogenetics can modify the activity of cell membrane transporters and cause variability in the pharmacokinetics of and response to their substrate drugs.
机译：这份MiniReview是个人对选定研究主题的回忆，作者与同事合作对其进行了研究，旨在提高药物治疗的可预测性。在早期研究中，我们发现二价和三价阳离子可减少各种四环素和氟喹诺酮类的吸收。某些抗酸药可提高某些非甾体类抗炎药和磺酰脲类的生物利用度。各种品牌的苯妥英片显示其生物利用度差异很大，从而导致临床后果。还研究了许多影响活性炭解毒效果的因素，并将木炭与其他胃肠道净化方法（包括吐根和洗胃）进行了比较。年龄和疾病对药物药代动力学的影响是一个研究课题。急性索他洛尔中毒显示出其QT延长的特性，甚至小剂量的莫氯贝米与血清素能药物的混合过量也被证明是致命的。伊曲康唑和其他有效的CYP3A4抑制剂可能会大大增加对咪达唑仑，三唑仑，丁螺环酮，洛伐他汀，辛伐他汀和羟考酮的药物的暴露，而利福平则大大降低了其血浆浓度。从有效抑制到诱导的变化导致口服咪达唑仑的暴露量变化了400倍。 CYP2C8被发现在几种药物的代谢和相互作用中至关重要。影响他汀类药物的许多相互作用是由CYP3A4介导的，但转运蛋白在某些相互作用中很重要。 Tizanidine对CYP1A2抑制非常敏感。葡萄柚汁等果汁可以增加或降低对不同药物的接触。药物相互作用和药物遗传学都可以改变细胞膜转运蛋白的活性，并引起底物药物的药代动力学和对其反应的变化。

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