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首页> 外文期刊>Journal of dermatological science >A pattern of association between clinical form of vitiligo and disease-related variables in a Brazilian population.
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A pattern of association between clinical form of vitiligo and disease-related variables in a Brazilian population.

机译：巴西人群中白癜风的临床形式与疾病相关变量之间的关联模式。

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BACKGROUND: Vitiligo classification systems are often based exclusively on the number and distribution of the white patches. To what extend these classification protocols reflect possible different pathophysiological basis for vitiligo or carry any prognostic value is currently unknown. OBJECTIVE: To investigate patterns of association between type of vitiligo and common disease-related variables, in order to advance on the understanding of the exact nature of different clinical forms of disease, as well as to identify features with prognostic value for clinical progression of early diagnosed vitiligo. MATERIALS AND METHODS: This is a cross-sectional study of a population sample from south of Brazil composed of 586 independent vitiligo-affected individuals. Different strategies of case-control analysis were employed to test for association between the three most common vitiligo clinical types and age of onset, family history of vitiligo, occurrence of Koebner phenomenon (KP) and presence of autoimmune co-morbidity. RESULTS: Individuals affected by segmental vitiligo showed lower average age of onset (16 years) when compared with vulgaris (23.9 years) and acrofacial cases (29 years) (p<0.001). The distribution of occurrence of KP, family history of vitiligo and co-occurrence of autoimmune disease followed a gradient pattern, with high, intermediate and low chance of occurrence of all three variables observed for vulgaris, acrofacial and segmental vitiligo, respectively (p<0.001 for overall distribution). CONCLUSION: Results indicate a uniform pattern of association between vitiligo clinical forms and KP, positive vitiligo family history and occurrence of co-morbidity autoimmune. The impact of the observed pattern of association over disease prognosis and classification is discussed.
机译：背景：白癜风分类系统通常仅基于白色斑块的数量和分布。这些分类方案在多大程度上反映出白癜风可能具有的不同病理生理基础或具有任何预后价值，目前尚不清楚。目的：探讨白癜风类型与常见疾病相关变量之间的关联模式，以加深对不同临床疾病形式的确切性质的了解，并鉴定对早期临床进展具有预后价值的特征诊断为白癜风。材料和方法：这是对巴西南部人口的样本进行的横断面研究，该样本由586名受白癜风影响的独立个体组成。病例对照分析的不同策略用于测试三种最常见的白癜风临床类型与发病年龄，白癜风家族史，Koebner现象（KP）的发生以及自身免疫性合并症之间的关联。结果：与普通寻常型（23.9岁）和杂技病例（29岁）相比，段性白癜风患者的平均发病年龄（16岁）低（p <0.001）。 KP的发生分布，白癜风家族史和自身免疫性疾病的并发呈梯度分布，分别观察到寻常型，杂技性和节段性白癜风的所有三个变量的发生率分别为高，中和低（p <0.001进行整体分配）。结论：结果表明白癜风临床形式与KP，白癜风家族史阳性和合并自身免疫性合并症之间存在统一的联系方式。讨论了观察到的关联模式对疾病预后和分类的影响。

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