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Over-expression of kallikrein related peptidases in palmoplantar pustulosis

机译:掌plant脓疱病中激肽释放酶相关肽酶的过表达

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摘要

Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a chronic pustular dermatitis characterized by palmoplantar intraepidermal vesicles filled with neutrophils. That very early vesicle formation occurs in the acrosyringium, and the sweat antimicrobial peptides, hCAP-18/LL-37 and dermcidin, are present in the vesicles of the palms and soles was discovered recently [1]. Also, IL-17 positive cell infiltration around the acrosyringium as well as IL-17 expression in the acrosyringeal cells has been reported [2].
机译:掌ust脓疱病或掌plant脓疱病(PPP)是一种慢性脓疱性皮炎,其特征在于掌plant内表皮囊泡中充满了中性粒细胞。最近发现,在顶头小囊泡中很早就形成了囊泡,最近发现手掌和足底的囊泡中存在汗液抗菌肽hCAP-18 / LL-37和真皮皮层蛋白[1]。另外,已经报道了在丙烯环周围的IL-17阳性细胞浸润以及在丙烯环鞘细胞中的IL-17表达[2]。

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