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首页> 外文期刊>Journal of dermatological science >Changes in photoinduced cutaneous erythema with topical application of a combination of vitamins C and E before and after UV exposure
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Changes in photoinduced cutaneous erythema with topical application of a combination of vitamins C and E before and after UV exposure

机译：在紫外线照射前后局部使用维生素C和E组合后，光诱发性皮肤红斑的变化

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Background: Ultraviolet radiation is harmful for human skin, and photodamaging pathologies such as actinic erythema, are formerly described as a consequence of UV direct effect on DNA and indirectly by local immune reactions. However, the degree of participation of oxidative stress in actinic erythema and the role of antioxidants in photoprotection are still not fully understood. Objective: To evaluate the possible palliative role of a combination of the antioxidants vitamins C and E in human cutaneous erythema when applied topically before and after UV exposure. Materials and methods: The study included 20 volunteers of phototypes II, II-III and III with no solar exposure for two months prior to the study. The volunteers were submitted to a phototest consisting on the analysis of the minimal erythemal dose (MED) under different treatments: 1. Untreated irradiated skin; 2. Irradiated skin previously treated with vehicle; 3. Irradiated skin previously treated with a combination of vitamins (2.5% vit E-5% vit C); and 4. Skin treated with the antioxidant combination after irradiation. Cutaneous erythema was evaluated 24. h after exposure and the MED was calculated for each treatment. Results: The application of vehicle did not significantly affect the MED compared to untreated irradiated skin. Application of the antioxidant combination, prior to irradiation, increased the MED in all phototypes compared with untreated irradiated skin with an average increase of 36.9%. Antioxidants applied after exposure promoted an average increase of the MED by 19.8%. Conclusions: Combination of topical antioxidants (vitamins C and E) shows photoprotection activity against erythema, mainly owing to their high absorption properties. Moreover, their antioxidant activity could be considered as additive, and independent of their optical properties.
机译：背景：紫外线辐射对人体皮肤有害，光损伤性疾病（如光化性红斑）以前被描述为紫外线直接作用于DNA的结果，是局部免疫反应间接作用的结果。然而，仍然没有完全了解氧化应激在光化性红斑中的参与程度以及抗氧化剂在光保护中的作用。目的：评估在紫外线照射前后局部使用抗氧化剂维生素C和E组合对人皮肤红斑的姑息作用。材料和方法：该研究包括20名志愿者，他们的照片类型为II，II-III和III，在研究前两个月内没有阳光照射。志愿者接受了光测试，该光测试包括在不同治疗情况下的最小红斑剂量（MED）分析：1.未经处理的辐照皮肤; 2.辐照过的皮肤事先用媒介物处理过; 3.事先用维生素（2.5％vit E-5％vit C）处理过的辐照皮肤; 4.在辐射后用抗氧化剂组合处理过的皮肤。暴露后24小时评估皮肤红斑，并计算每种治疗的MED。结果：与未经处理的辐照皮肤相比，载体的应用对MED的影响不明显。与未经处理的受辐照皮肤相比，在辐照前应用抗氧化剂组合可提高所有照相型的MED水平，平均提高36.9％。暴露后施用的抗氧化剂使MED平均增加19.8％。结论：局部抗氧化剂（维生素C和E）的组合显示出对红斑的光保护活性，这主要归因于其高吸收性能。而且，它们的抗氧化剂活性可以被认为是添加剂，并且与它们的光学性质无关。

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