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首页> 外文期刊>Journal of dermatological science >A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type
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A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type

机译：一组无IgE升高或屏障障碍的特应性皮炎显示高Th1频率：固有型可能的免疫状态

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Background: Atopic dermatitis (AD) can be classified into the major extrinsic type with high serum IgE levels and impaired barrier, and the minor intrinsic type with normal IgE levels and unimpaired barrier. Objective: To characterize the intrinsic type of Japanese AD patients in the T helper cell polarization in relation to the barrier condition. Methods: Enrolled in this study were 21 AD patients with IgE < 200. kU/L (IgE-low group; 82.5 ± 59.6. kU/L) having unimpaired barrier, and 48 AD patients with IgE > 500. kU/L (IgE-high group; 8.050 ± 10.400. kU/L). We investigated filaggrin gene (FLG) mutations evaluated in the eight loci common to Japanese patients, circulating Th1, Th2 and Th17 cells by intracellular cytokine staining and flow cytometry, and blood levels of CCL17/TARC, IL-18, and substance P by ELISA. Results: The incidence of FLG mutations was significantly lower in the IgE-low group (10.5%) than the IgE-high group (44.4%) (normal individuals, 3.7%). The percentage of IFN-γ-producing Th1, but not Th2 or Th17, was significantly higher in the IgE-low than IgE-high group. Accordingly, Th2-attracting chemokine CCL17/TARC, was significantly lower in the IgE-low than the IgE-high group. There were no differences between them in serum IL-18 levels, or the plasma substance P levels or its correlation with pruritus. Conclusion: The IgE-low group differed from the IgE-high group in that it had much less FLG mutations, increased frequency of Th1 cells, and lower levels of CCL17. In the intrinsic type, non-protein antigens capable of penetrating the unimpaired barrier may induce a Th1 eczematous response.
机译：背景：特应性皮炎可分为血清IgE水平高和屏障受损的主要外源性类型，以及IgE水平正常和屏障未受损的轻度内在类型。目的：鉴定日本AD患者的T型辅助细胞极化与障碍状况有关的内在类型。方法：该研究招募了21例IgE <200. kU / L的AD患者（IgE较低的组; 82.5±59.6。kU / L），其屏障没有受损，以及48例IgE> 500. kU / L（IgE）的AD患者。 -高组; 8.050±10.400。kU / L）。我们调查了在日本患者共有的8个基因座中评估的丝聚蛋白基因（FLG）突变，通过细胞内细胞因子染色和流式细胞术检测循环的Th1，Th2和Th17细胞以及通过ELISA测定的血液中CCL17 / TARC，IL-18和P物质的水平。结果：低IgE组（10.5％）的FLG突变发生率明显低于高IgE组（44.4％）（正常人为3.7％）。在低IgE组中，产生IFN-γ的Th1的百分比显着高于高IgE组，但不产生Th2或Th17。因此，在低IgE组中，吸引Th2的趋化因子CCL17 / TARC明显低于高IgE组。它们之间的血清IL-18水平或血浆P物质水平或与瘙痒的相关性无差异。结论：低IgE组与高IgE组的区别在于其FLG突变少得多，Th1细胞频率增加，CCL17水平较低。在固有类型中，能够穿透未受损屏障的非蛋白质抗原可能诱导Th1湿疹反应。

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