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首页> 外文期刊>British Journal of Dermatology >Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis.
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Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis.

机译：IgE高外源性和IgE正常内源性特应性皮炎之间的皮肤屏障功能和感觉神经电流知觉阈值的比较。

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Background Two types of atopic dermatitis (AD) have been proposed, with different pathophysiological mechanisms underlying this seemingly heterogeneous disorder. The extrinsic type shows high IgE levels presumably as a consequence of skin barrier damage and feasible allergen permeation, whereas the intrinsic type exhibits normal IgE levels and is not mediated by allergen-specific IgE. Objectives To investigate the relationship between pruritus perception threshold and skin barrier function of patients with AD in a comparison between the extrinsic and intrinsic types. Methods Enrolled in this study were 32 patients with extrinsic AD, 17 with intrinsic AD and 24 healthy individuals. The barrier function of the stratum corneum was assessed by skin surface hydration and transepidermal water loss (TEWL), and pruritus perception was evaluated by the electric current perception threshold (CPT) of sensory nerves upon neuroselective transcutaneous electric stimulation. Results Skin surface hydration was significantly lower and TEWL was significantly higher in extrinsic AD than intrinsic AD or normal controls. Although there was no statistically significant difference in CPT among extrinsic AD, intrinsic AD and normal controls, CPT was significantly correlated with skin surface hydration and inversely with TEWL in intrinsic AD and normal controls, but not extrinsic AD. Finally, CPT was correlated with the visual analogue scale of itch in the nonlesional skin of patients with extrinsic but not intrinsic AD. Conclusions Patients with extrinsic AD have an impaired barrier, which increases the pre-existing pruritus but rather decreases sensitivity to external stimuli. In contrast, patients with intrinsic AD retain a normal barrier function and sensory reactivity to external pruritic stimuli.
机译：背景技术已经提出了两种类型的特应性皮炎（AD），具有不同的病理生理机制作为这种看似异质性疾病的基础。外在型表现出较高的IgE水平，可能是由于皮肤屏障破坏和可行的过敏原渗透所致，而内在型表现出正常的IgE水平，且不受过敏原特异性IgE介导。目的通过比较外在和内在类型，探讨AD患者的瘙痒性知觉阈值与皮肤屏障功能之间的关系。方法纳入本研究的32例外源性AD患者，17例内源性AD患者和24例健康个体。通过皮肤表面水合作用和表皮水分流失（TEWL）评估角质层的屏障功能，并通过神经选择性经皮电刺激通过感觉神经的电流感知阈值（CPT）评估瘙痒感。结果外源性AD的皮肤表面水合明显低于内源性AD或正常对照组，而TEWL则明显高于内源性AD或正常对照组。尽管外源性AD，内在性AD和正常对照组之间CPT差异无统计学意义，但内源性AD和正常对照组中CPT与皮肤表面水化显着相关，而TEWL与皮肤表面水化呈显着相关，而外源性AD则与CWL呈负相关。最后，CPT与外在性但非固有性AD患者的非病变皮肤瘙痒的视觉模拟评分相关。结论外源性AD患者的屏障功能受损，增加了既有的瘙痒症，但降低了对外界刺激的敏感性。相比之下，具有固有AD的患者保留正常的屏障功能和对外部瘙痒刺激的感觉反应。

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