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首页> 外文期刊>Journal of dermatological science >Psoriatic patients with diabetes are prone to develop digestive organ cancers: A population-based study in Taiwan
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Psoriatic patients with diabetes are prone to develop digestive organ cancers: A population-based study in Taiwan

机译：银屑病糖尿病患者容易发生消化器官癌：台湾一项基于人群的研究

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Background: Psoriasis is an inflammatory skin condition. Epidemiology studies from different parts of the world have shown that psoriasis is associated with different components of metabolic syndrome. The association between psoriasis and development of cancer has not yet been clearly established. Objective: We hypothesize that chronic inflammation is the driving force that enhances the risk of malignancy in psoriatic patients and suspect that psoriatic patients have higher risks for developing cancers that are most prevalent in the studied population. Methods: Using the nested case-control approach derived from the Taiwanese population-based cohort, the current study was launched to validate this hypothesis. Results 8180 psoriatic patients and 163,600 age-matched controls were included in this study. Psoriatic patients were 1.20 folds (95% CI = 1.06-1.36; p=0.004) more likely than controls to develop cancer. Further analyses revealed that incident cancers derived from digestive tract, the most common cancer origin found in Taiwanese population, were most significantly associated psoriasis. Patients with psoriasis and diabetes mellitus, a frequent comorbid condition independently associate with both psoriasis and cancer, conferred the highest risk for developing digestive tract cancers, having risks of 1.98 folds (95% CI: 1.11-3.52) and 1.68 folds (95%CI: 1.23-2.28) for the 41-60. years-old and 61-80. years-old age group, respectively. Both psoriasis and diabetes were independently associated with development of digestive tract cancers in the 41-60. years-old patient group. Conclusion: Prevalent cancers in the population should be carefully monitored in the psoriatic patients after middle age (beyond 40. years of age) especially for those with concomitant diabetic conditions.
机译：背景：牛皮癣是一种炎症性皮肤病。来自世界各地的流行病学研究表明，牛皮癣与代谢综合征的不同成分有关。银屑病与癌症发展之间的关联尚未明确建立。目的：我们假设慢性炎症是增加银屑病患者恶性肿瘤风险的驱动力，并怀疑银屑病患者患上研究人群中最普遍的癌症的风险更高。方法：使用源自台湾人群队列的嵌套病例对照方法，开展了当前研究以验证该假设。结果本研究包括8180名银屑病患者和163,600名年龄匹配的对照。银屑病患者罹患癌症的可能性比对照组高1.20倍（95％CI = 1.06-1.36; p = 0.004）。进一步的分析表明，台湾人群中最常见的癌症起源于消化道，是牛皮癣的最主要来源。牛皮癣和糖尿病患者，一种常见的合并症，独立于牛皮癣和癌症，并发消化道癌的风险最高，风险为1.98倍（95％CI：1.11-3.52）和1.68倍（95％CI） ：1.23-2.28）（41-60）。岁和61-80岁。岁年龄段分别。银屑病和糖尿病都与41-60岁的消化道癌症的发生独立相关。岁患者组。结论：中年后（超过40岁）的银屑病患者应仔细监测人群中普遍存在的癌症，尤其是那些患有糖尿病的患者。

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