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首页> 外文期刊>Journal of dermatological science >Correlation between serum thymus and activation-regulated chemokine levels and stratum corneum barrier function in healthy individuals and patients with mild atopic dermatitis
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Correlation between serum thymus and activation-regulated chemokine levels and stratum corneum barrier function in healthy individuals and patients with mild atopic dermatitis

机译：健康个体和轻度特应性皮炎患者血清胸腺与活化调节趋化因子水平和角质层屏障功能的相关性

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Background: Serum thymus and activation-regulated chemokine (TARC) levels closely reflect the disease activity of atopic dermatitis (AD). AD is characterized by impaired epidermal barrier function and atopic dry skin. However, dry skin is also a very common problem in healthy individuals. Objective: To investigate the relationship between serum TARC levels and epidermal barrier function in healthy subjects and patients with mild AD. Methods: This study included 2 groups, 121 healthy subjects (healthy group) and 66 patients with mild AD (mild AD group). Barrier function was assessed by transepidermal water loss (TEWL) and stratum corneum hydration (SCH). Results: Significantly elevated serum TARC levels and TEWL values and significantly decreased SCH values were detected in the mild AD group compared to those in the healthy group. In the mild AD group, serum TARC levels were significantly correlated with TEWL values and were inversely correlated with SCH values. Importantly, serum TARC levels were also inversely correlated with SCH values in the healthy controls. TEWL values in the healthy group tended to be correlated with TARC levels but did not reach statistical significance. Conclusion: Together with TEWL and SCH, serum TARC level is a useful biomarker, reflecting impairment of epidermal function in AD patients as well as healthy subjects.
机译：背景：血清胸腺和激活调节趋化因子（TARC）的水平密切反映了特应性皮炎（AD）的疾病活动。 AD的特征在于表皮屏障功能受损和特应性干性皮肤。然而，皮肤干燥也是健康个体中非常普遍的问题。目的：探讨健康人群和轻度AD患者血清TARC水平与表皮屏障功能的关系。方法：本研究包括2组，121名健康受试者（健康组）和66名轻度AD患者（轻度AD组）。屏障功能通过表皮失水（TEWL）和角质层水合作用（SCH）进行评估。结果：与健康组相比，轻度AD组的血清TARC水平和TEWL值显着升高，而SCH值显着降低。在轻度AD组中，血清TARC水平与TEWL值显着相关，而与SCH值呈负相关。重要的是，健康对照组中血清TARC水平也与SCH值呈负相关。健康组的TEWL值倾向于与TARC水平相关，但未达到统计学意义。结论：血清TEC水平与TEWL和SCH一起是有用的生物标志物，反映了AD患者和健康受试者的表皮功能受损。

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