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首页> 外文期刊>Journal of dermatological science >Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model
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Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model

机译：口服胶原蛋白三肽可改善丙酮引起的皮肤干燥模型的干燥和瘙痒

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Background: Dry skin causes pruritus and discomfort in patients with xerosis and atopic dermatitis. General treatment for skin dryness involves the topical application of an emollient. However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic collagen fraction that is known to have various biological effects. Objective: To clarify the therapeutic effects of CTP for dry skin using acetone-induced dry skin model mice. Methods: ICR mice were treated with acetone followed by oral administration of CTP (80 or 500. mg/kg/day) for 3 days. Hyaluronic acid production induced by CTP was assessed using human dermal fibroblasts in vitro and in an acetone-induced dry skin model mice in vivo. Transepidermal water loss (TEWL) and scratching behavior were evaluated. Furthermore, the effects of CTP on intraepidermal nerve fibers and expression of semaphorin 3A (Sema3A) and nerve growth factor (NGF) were examined by immunohistochemistry and quantitative RT-PCR. Results: CTP enhanced hyaluronic acid production in human dermal fibroblasts in vitro and in murine skin in vivo. Oral administration of CTP in acetone-induced dry skin model mice significantly decreased TEWL and suppressed scratching behavior. Intraepidermal nerve growth was dramatically inhibited in CTP-treated mice. Quantitative PCR analysis and immunohistochemical study revealed that CTP abolished the increased NGF and decreased Sema3A levels induced by acetone treatment. Conclusion: Oral administration of CTP improves dry skin and normalizes axon-guidance factors in the epidermis in addition to reducing pruritus. CTP may be used in a new therapeutic strategy against dry skin and pruritus.
机译：背景：皮肤干燥会导致干燥症和特应性皮炎患者瘙痒和不适。皮肤干燥的一般治疗包括局部使用润肤剂。但是，需要更有效，更简单的疗法。胶原蛋白三肽（CTP）是一种高度纯化的非抗原性，低过敏性胶原蛋白组分，已知具有多种生物学作用。目的：阐明丙酮诱导的干性皮肤模型小鼠CTP对干性皮肤的治疗作用。方法：用丙酮处理ICR小鼠，然后口服CTP（80或500. mg / kg /天），持续3天。在体外和在丙酮诱导的干性皮肤模型小鼠体内，使用人皮肤成纤维细胞评估了由CTP诱导的透明质酸产生。评估了表皮失水（TEWL）和抓挠行为。此外，通过免疫组织化学和定量RT-PCR检查了CTP对表皮内神经纤维和semaphorin 3A（Sema3A）和神经生长因子（NGF）表达的影响。结果：CTP增强了人皮肤成纤维细胞体外和体内鼠皮肤中透明质酸的产生。在丙酮诱导的干性皮肤模型小鼠中口服CTP可显着降低TEWL并抑制抓挠行为。在经CTP处理的小鼠中，表皮神经的生长受到显着抑制。定量PCR分析和免疫组织化学研究表明，CTP消除了丙酮处理诱导的NGF升高和Sema3A水平降低。结论：口服CTP不仅可以改善皮肤干燥，还可以使表皮中的轴突引导因子正常化，还可以减少瘙痒症。 CTP可用于针对皮肤干燥和瘙痒的新治疗策略。

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