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首页> 外文期刊>Journal of dermatological science >Transcriptional control of skin reepithelialization
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Transcriptional control of skin reepithelialization

机译：皮肤再上皮化的转录控制

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摘要

The wound healing process is characterized by a series of overlapping phases, such as coagulation, inflammation, reepithelialization/granulation tissue generation and remodeling.It is important to obtain a deeper insight into the cutaneous wound repair mechanisms, in order to develop novel pharmacological tools for the treatment of chronic non-healing ulcers which are a frequent and high morbidity complication of diabetes, ischaemia, venous insufficiency, and other local or systemic factors. Several transcription factors, many of which belong to gene families, are known to play a role in cutaneous wound repair through the orchestration of cellular responses which promote the reconstitution of skin integrity.The aim of this review is to provide an updated analysis of the transcription factor role in the reepithelialization process, in the context of skin wound repair.
机译：伤口愈合过程的特征是一系列重叠的阶段，例如凝血，炎症，再上皮化/肉芽组织生成和重塑。重要的是深入了解皮肤伤口修复机制，以开发新的药理学工具用于慢性非治愈性溃疡的治疗，这些溃疡是糖尿病，局部缺血，静脉功能不全以及其他局部或全身性因素的常见且高发病率并发症。已知许多转录因子（其中许多属于基因家族）通过协调促进皮肤完整性重构的细胞应答在皮肤伤口修复中发挥作用。本综述的目的是提供转录的最新分析在皮肤伤口修复的背景下，因子在再上皮化过程中的作用。

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