DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives.

Burli RW; McMinn D; Kaizerman JA; Hu W; Ge Y; Pack Q; Jiang V; Gross M; Garcia M; Tanaka R; Moser HE

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives.

机译：靶向耐药革兰氏阳性细菌的DNA结合配体。第1部分：内部苯并咪唑衍生物。

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摘要

Novel DNA minor-groove binding ligands with a promising antibacterial profile are described. Apart from excellent in vitro potency against multiple Gram-positive bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), and penicillin-intermediate Streptococcus pneumoniae (PISP), a small subset of compounds was active against Gram-negative bacteria such as Escherichia coli (E. coli).

机译：描述了具有希望的抗菌谱的新型DNA次要沟槽结合配体。除了对多种革兰氏阳性细菌菌株（例如耐甲氧西林的金黄色葡萄球菌（MRSA），耐万古霉素的粪肠球菌（VRE）和青霉素中间的肺炎链球菌（PISP））具有出色的体外效力外，一小部分化合物具有活性抵抗革兰氏阴性细菌，例如大肠杆菌（E. coli）。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2004年第5期|共5页
作者
Burli RW; McMinn D; Kaizerman JA; Hu W; Ge Y; Pack Q; Jiang V; Gross M; Garcia M; Tanaka R; Moser HE;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Bacterial; binding; DNA; targeting; Part;

机译：细菌;结合;DNA;靶向;部分;

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专利

1. DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives. [J] . Burli RW, McMinn D, Kaizerman JA, Bioorganic and Medicinal Chemistry Letters . 2004,第5期

机译：靶向耐药革兰氏阳性细菌的DNA结合配体。第1部分：内部苯并咪唑衍生物。
2. DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria. [J] . Burli R, Ge Y, White S, Bioorganic and Medicinal Chemistry Letters . 2002,第18期

机译：DNA结合配体具有极强的抗药性革兰氏阳性细菌的抗生素效能。
3. DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology [J] . Jacob A. Kaizerman, Matthew I. Gross, Yigong Ge, Journal of Medicinal Chemistry . 2003,第18期

机译：靶向耐药细菌的DNA结合配体：结构，活性和药理学。
4. Predicting target-ligand interactions using protein ligand-binding site and ligand substructures [C] . Caihua Wang, Juan Liu, Fei Luo, Asia-Pacific Bioinformatics Conference . 2015

机译：使用蛋白质配体结合位点和配体亚结构预测靶 - 配体相互作用
5. Design, synthesis and analysis of DNA minor groove binding amino acid-benzimidazole conjugates. [D] . Li, Bo. 2009

机译：DNA小沟结合氨基酸-苯并咪唑结合物的设计，合成和分析。
6. Regeneration of insertionally inactivated streptococcal DNA fragments after excision of transposon Tn916 in Escherichia coli: strategy for targeting and cloning of genes from gram-positive bacteria. [O] . C Gawron-Burke, D B Clewell 1984

机译：在大肠杆菌中转座子Tn916切除后插入的灭活链球菌DNA片段的再生：靶向和克隆革兰氏阳性细菌基因的策略。
7. Synthesis and Characterization of the Ligand Based on Benzimidazole and Its Copper Complex: DNA Binding and Antioxidant Activity [O] . Wu, Huilu, Kou, Fan, Jia, Fei, 2011

机译：基于苯并咪唑及其铜配合物的配体的合成与表征：DNA结合和抗氧化活性

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives.

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