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首页> 外文期刊>Journal of cosmetic and laser therapy >Enhanced efficacy of a topical antioxidants regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin
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Enhanced efficacy of a topical antioxidants regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin

机译：局部抗氧化剂方案与家用非烧蚀性分级二极管激光器一起在光损伤的面部皮肤中的功效增强

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Background: Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes. Objective: To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage. Methods: This was a 49-subject, evaluator-blinded, split-face, randomized, single-center, 24-week, phase-2, study. In phase 1, all subjects were treated on one facial side with test products and a home-use laser device and the other side was treated with laser alone for 12 weeks, followed by a 2-week regression period during which they used only support materials. For phase 2, all subjects were divided into 2 independent treatment groups. For the next 10 weeks, subjects of first group treated the assigned facial side with test products and support materials and the other facial side with only support materials. Subjects in the second group treated their entire face with only support materials. Efficacy and tolerance were assessed by clinical grading, VISIA-CR imaging, and self-assessment questionnaires. Results: The combination of laser and test products improved all photodamage parameters evaluated. Conclusion: The test products enhanced and prolonged clinical benefits obtained with the laser alone.
机译：背景：光损伤的面部皮肤的特征是细纹和皱纹，斑驳的色素沉着和其他变化。目的：评估和比较家用激光设备单独使用或与抗氧化剂面部护理组合使用以治疗中度光损伤的功效和耐受性。方法：这是一项49名受试者，评估者盲目，裂脸，随机，单中心，24周，2期研究。在第1阶段，所有受试者的一侧接受测试产品和家用激光设备治疗，另一侧接受单独激光治疗12周，然后进行2周的消退期，在此期间，他们仅使用支持材料。对于阶段2，将所有受试者分为2个独立的治疗组。在接下来的10周中，第一组受试者用测试产品和支持材料治疗分配的面部，而仅使用支持材料治疗另一面部。第二组中的受试者只用支持材料治疗了整个面部。通过临床分级，VISIA-CR成像和自我评估问卷评估疗效和耐受性。结果：激光和测试产品的组合改善了所有评估的光损伤参数。结论：单独使用激光可以增强并延长测试产品的临床效果。

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