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Biological applications of electrostatic surface field effects

机译:静电表面场效应的生物应用

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This paper presents a few biological applications of surface field effects, including dielectrophoresis (DEP), electroosmotic flow (EOF) and liquid actuation. The stretch-and-positioning of DNA based on DEP enables the space-resolved observation of molecular interactions in single-molecule level, with its present application in gene location, and future application in DNA-based molecular constructions. Large genome DNA can be extended from a cell and placed on a chip with the use of EOF with variable flow direction. Electrostatic liquid actuation can be used for rapid transport and dispensing of nanoliter volume of liquids. Due to simplicity and compatibility with micro-fabrication, these surface field-effects are expected to provide convenient methodologies and tools for particle, molecule, and liquid manipulation in on-chip micro-biochemical systems. (c) 2005 Elsevier B.V. All rights reserved.
机译:本文介绍了表面场效应的一些生物学应用,包括介电泳(DEP),电渗流(EOF)和液体驱动。基于DEP的DNA拉伸和定位技术可以在单分子水平上对分子相互作用进行空间分辨的观察,其目前在基因定位中的应用以及未来在基于DNA的分子构建中的应用。可以使用具有可变流动方向的EOF,从细胞中扩增大基因组DNA,并放置在芯片上。静电液体致动可用于快速运输和分配纳升体积的液体。由于其简单性以及与微加工的兼容性,这些表面场效应有望为芯片上微生化系统中的颗粒,分子和液体处理提供便捷的方法和工具。 (c)2005 Elsevier B.V.保留所有权利。

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