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首页> 外文期刊>Journal of cosmetic dermatology >Treatment of palmar hyperhidrosis with botulinum toxin type A: 44 months of experience
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Treatment of palmar hyperhidrosis with botulinum toxin type A: 44 months of experience

机译：A型肉毒杆菌毒素治疗手多汗症：44个月的经验

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Background Palmar hyperhidrosis (PH) can produce social and occupational difficulties and reduce the quality of life of those who suffer from this kind of problem. When dealing with focal hyperhidrosis, the patients' attitudes and their subjective approaches regarding the process may influence the objective evaluation of the disorder.Objective To evaluate, by means of a scale, the subjective improvement of sweat production after treatment with botulinum toxin type A (BTX-A) in a group of patients with severe, invalidating PH.Patients and methods Over a period of 44 months, 69 patients were treated and followed-up, 2 7 patients had to be treated twice, and 11 patients required a third application; 80-100 U was injected in each palm. Regional nerve block was performed before the procedure. The patients were asked to evaluate their improvement at 1, 3, 6, 9, and 12 months of baseline.Results At 1 month, 53.6% of the patients reported an excellent improvement. Three months later, results were still excellent in 33.3% of the patients, and acceptable in 29%. From then on there was a statistically significant decrease of BTX-A effectiveness. A second application was carried out at an interval of 7.5 (+-) 2.6 months, and a third one at 9 (+-) 4.4 months. The following complications could be observed: transitory weakness of hand muscles in 13 patients, wrist pain in 5 patients, and cramps in 1 patient.Conclusions Botulinum toxin is an effective alternative for the treatment of severe, invalidating PH. The maximum improvement persists up to 3 months; from then on, the effects slowly diminish. In our experience, there were no statistically significant differences with further applications of BTX-A. The patients' subjective assessment can be used to evaluate the sweat production after treatment with BTX-A in those medical centers where a more objective evaluation becomes difficult or impossible.
机译：背景手掌多汗症（PH）会产生社会和职业困难，并降低遭受此类问题困扰的人们的生活质量。当处理局灶性多汗症时，患者对过程的态度及其主观态度可能会影响对疾病的客观评估。 BTX-A）在一组严重的PH无效患者中。患者和方法在44个月的时间里，对69例患者进行了治疗和随访，其中2 7例患者必须接受两次治疗，而11例患者需要进行第三次应用;每只手掌注入80-100U。手术前进行区域神经阻滞。要求患者在基线1、3、6、9和12个月时评估他们的改善情况。结果在1个月时，有53.6％的患者报告有良好的改善。三个月后，在33.3％的患者中结果仍然出色，在29％的患者中可接受。从那时起，BTX-A有效性在统计学上显着下降。第二次施用间隔为7.5（+/-）2.6个月，第三次施用间隔为9（+/-）4.4个月。可以观察到以下并发症：13例患者手部肌肉短暂性肌无力，5例患者腕部疼痛，1例患者痉挛。结论肉毒杆菌毒素是治疗严重的无效PH的有效替代方法。最大的改善持续到3个月;从那时起，效果逐渐减弱。根据我们的经验，BTX-A的进一步应用没有统计学上的显着差异。患者的主观评估可用于在难以或不可能进行更客观评估的医疗中心评估BTX-A治疗后的出汗量。

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