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首页> 外文期刊>Journal of Economic Entomology >Efficacy of Eprinomectin and Doramectin Against Amblyomma americanum (Acari: Ixodidae) on Cattle
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Efficacy of Eprinomectin and Doramectin Against Amblyomma americanum (Acari: Ixodidae) on Cattle

机译：柔美菌素和多拉菌素对美国牛A（牛痘）的功效

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Steers were treated with doramectin or eprinomectin by daily oral capsule for 28 consecutive days. The level of doramectin in the serum of steers treated at 200 μg/kg/d reached a maximum of 104.0 ± 22.1 ppb at day 21 and declined from 93.3 ± 20.5 ppb on the final day of treatment to below detectable by day 56. Steers treated at 50 μg/ kg/ d reached a maximum level of doramectin in the serum of 24.7 ± 1.2 ppb on day 21 and declined from 24.7 ± 0.6 ppb on the final day of treatment to less than detectable on day 42. Both doramectin dosages provided 100% control of estimated larvae (EL) of Amblyomma americanum (L.) (Acari: Ixodidae) throughout the 28-d treatment period. Daily oral treatment with eprinomectin at a dosage of 200 μg/kg for 28 consecutive days produced a maximum concentration in the serum of 41.6 ± 11.0 ppb at day 14. On the final day of eprinomectin treatment, the serum concentration was 38.3 ± 5.9 ppb. Seven days later at day 35, eprinomectin was not detectable in the serum. For steers treated at 50 μg/kg/d for 28 consecutive days, the serum level of eprinomectin reached a maximum of 10.0 ± 3.0 ppb on day 28 and was undetectable on day 35. Both eprinomectin dosages provided complete control of EL of A. americanum during the 28-d treatment period. Because eprinomectin is efficacious against A. americanum at lower serum levels in cattle and is eliminated from the serum at a more rapid rate than either doramectin or ivermectin, it provides advantages for use in applications such as the medicated bait for control of ticks on white-tailed deer and could have potential for use in the Cattle Fever Tick Eradication Program.
机译：每天口服胶囊用doramectin或eprinomectin处理牛皮，连续28天。在第21天，以200μg/ kg / d处理的公牛血清中的doramectin水平达到最高104.0±22.1 ppb，从治疗的最后一天的93.3±20.5 ppb降至第56天可检测到的以下水平。剂量为50μg/ kg / d时，第21天的血清中多拉菌素的最高水平为24.7±1.2 ppb，从治疗的最后一天的24.7±0.6 ppb下降至第42天的可检测水平。两种多拉菌素剂量均可提供100在整个28天的治疗期内，估计的美洲盲mb（L.）（Acari：Ixodidae）幼虫（EL）的控制百分比。每天连续200天用200μg/ kg剂量的依普连菌素口服治疗，在第14天的血清中最大浓度为41.6±11.0 ppb，在依普连菌素治疗的最后一天，血清浓度为38.3±5.9 ppb。 7天后第35天，在血清中未检测到依普诺菌素。对于连续28天以50μg/ kg / d处理的公牛，在第28天，依普利菌素的血清水平达到最高10.0±3.0 ppb，在第35天无法检测到。两种依普利菌素剂量均可完全控制美洲曲霉的EL。在28天的治疗期间。因为依普连菌素在牛的血清水平较低时对美洲曲霉有效，并且以比多拉菌素或伊维菌素更快的速度从血清中清除，因此它在诸如用于控制白-上的虱子的药饵等应用中具有优势。尾鹿，可能有潜力在牛瘟的F灭计划中使用。

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