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首页> 外文期刊>Journal of endourology >Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding x-ray-positive poly-l,d -lactide spiral partial ureteral stent: an experimental study.
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Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding x-ray-positive poly-l,d -lactide spiral partial ureteral stent: an experimental study.

机译：一种可生物降解的自增强，自膨胀x射线阳性聚l，d-丙交酯螺旋部分输尿管支架的引流和抗反流特性：一项实验研究。

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Purpose: To evaluate the drainage and antireflux characteristics of a new self-expandable self-reinforced poly-L,D -lactide partial ureteral stent (SR-PLA 96) in an experimental model. Materials and Methods: Twelve dogs were used as experimental animals. A low-midline laparotomy and cystotomy were performed on all animals. In group A (six animals), 50-mm long SR-PLA 96 ureteral stents with a double-helical spiral design were inserted into both ureters, leaving the lower ends 2 cm above the ureterovesical junction. In group B (six animals), both ureters were stented with traditional pigtail stents (C-Flex((R)) Double-J; Cook Urological), which were removed 8 weeks after surgery. Renal function and ureteral patency were evaluated by dynamic kidney imaging and urography examinations at 6 and 12 weeks postoperatively. The degrees of vesicoureteral reflux at two levels of the ureters and at the level of the renal pelvis were evaluated by nuclear voiding cystograms at 6 weeks. Results: The partial SR-PLA 96 stent design showed more favorable antireflux properties that the Double-J stent design. The degree of vesicoureteral reflux, reflected in an increase of nuclear enhancement at 6 weeks, was lower in the distal (7.9% +/- 14.7% v 63.2% +/- 17.3%; P < 0.05) and middle (6.1% +/- 8.1% v. 45.5% +/- 19.5%; P = 0.15) levels of the ureters as well as at the level of the renal pelvis (-3.4% +/- 3.6% v 6.2% +/- 3.9%; P = 0.65) than in the Double-J-stented ureters. No significant differences in renal function or ureteral patency were observed at 12 weeks after the Double-J stents had been removed and the SR-PLA 96 stents had fragmented. Conclusion: A self-expandable, self-reinforced SR-PLA 96 partial ureteral stent showed more favorable antireflux properties than a Double-J stent.
机译：目的：在实验模型中评估新型自膨胀自增强聚L，D-丙交酯部分输尿管支架（SR-PLA 96）的引流和抗反流特性。材料和方法：将十二只狗用作实验动物。对所有动物进行低中线剖腹术和膀胱切开术。在A组（六只动物）中，将具有双螺旋螺旋设计的50毫米长SR-PLA 96输尿管支架插入两个输尿管中，其下端在输尿管-血管交界处上方2厘米处留出。在B组（六只动物）中，两个输尿管均用传统的猪尾支架（C-Flex（R）Double-J; Cook Urologic）进行支架植入，在术后8周将其移除。术后6周和12周通过动态肾脏成像和尿路造影检查评估肾功能和输尿管通畅性。在6周时通过核腔膀胱造影检查评估输尿管两个水平和肾盂水平的膀胱输尿管反流程度。结果：部分SR-PLA 96支架设计显示出比Double-J支架设计更好的抗回流特性。膀胱输尿管反流程度反映在第6周核增强的增加，在远端（7.9％+/- 14.7％vs 63.2％+/- 17.3％; P <0.05）和中间（6.1％+ / -输尿管水平以及肾盂水平分别为8.1％对45.5％+/- 19.5％; P = 0.15）（-3.4％+/- 3.6％v 6.2％+/- 3.9％; P = 0.65），而不是使用双J支架输尿管。在拔除Double-J支架并破碎SR-PLA 96支架后12周，肾功能或输尿管通畅性没有明显差异。结论：自膨胀，自增强的SR-PLA 96部分输尿管支架显示出比Double-J支架更有利的抗回流特性。

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