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首页> 外文期刊>Journal of contemporary psychotherapy >Discrepancy between cystatin C and creatinine points leading to a diagnosis of postrenal acute kidney injury and its reversibility: three case reports
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Discrepancy between cystatin C and creatinine points leading to a diagnosis of postrenal acute kidney injury and its reversibility: three case reports

机译：胱抑素C和肌酐值之间的差异导致肾后急性肾损伤的诊断及其可逆性：三例报告

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摘要

We report on three patients with postrenal acute kidney injury (AKI) showing a remarkably low level of cystatin C (CysC) compared with that of creatinine (Cr). The levels of Cr and CysC (Cr/CysC) were respectively as follows: 12.16 mg/dl/1.26 mg/l, 17.92 mg/dl/0.95 mg/l and 18.94 mg/dl/0.55 mg/l. The causes of urinary tract obstruction were benign prostatic hypertrophy, urinary bladder carcinoma and urethral stenosis due to radiation therapy for bladder carcinoma. Renal function was promptly recovered after relief of the obstruction. It is considered that the discrepancy strongly indicated AKI because of urinary tract obstruction and encouraged relief of the obstruction in order to recover renal function. Although the precise mechanism for the discrepancy was not determined, the maintenance of glomerular filtration and proximal tubular reabsorption of CysC long after the cessation of Cr excretion because of urinary tract obstruction seemed to be involved. This finding may be beneficial for the diagnosis and reversal of postrenal AKI and provides new insight into the process of postrenal AKI.
机译：我们报告了三例肾后急性肾损伤（AKI）患者的血浆胱抑素C（CysC）与肌酐（Cr）相比明显降低。 Cr和CysC的水平（Cr / CysC）分别如下：12.16mg / dl / 1.26mg / l，17.92mg / dl / 0.95mg / l和18.94mg / dl / 0.55mg / l。尿路梗阻的原因包括前列腺肥大，膀胱癌和因放疗导致的尿道狭窄。梗阻缓解后，肾功能迅速恢复。人们认为，由于尿路阻塞，该差异强烈地表明了AKI，并鼓励缓解阻塞以恢复肾功能。尽管尚未确定差异的确切机制，但似乎由于尿路阻塞而导致在停止Cr排泄后很长一段时间内维持CysC的肾小球滤过和近端肾小管重吸收。这一发现可能对肾后AKI的诊断和逆转有益，并为肾后AKI的过程提供新的见解。

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