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首页> 外文期刊>Journal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology >Short children with familial short stature show enhancement of somatotroph secretion but normal IGF-I levels.
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Short children with familial short stature show enhancement of somatotroph secretion but normal IGF-I levels.

机译：身材矮小，身材矮小的儿童表现出生长激素分泌增加，但IGF-I水平正常。

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摘要

The aim of the present study was to evaluate the GH status in children with familial, idiopathic short stature (FSS). To this goal we evaluated the GH response to GHRH (1 microg/kg iv) + arginine (ARG) (0.5 g/kg iv) test which is one of the most potent and reproducible provocative tests of somatotroph secretion, in 67 children with FSS [50 boys and 17 girls, age 10.8+/-0.4 yr, pubertal stages I-III, height between -3.6 and -1.6 standard deviation score (SDS), target height <10 degrees centile, normality of both spontaneous and stimulated GH secretion as well as of IGF-I levels]. The results in FSS were compared with those in groups of children of normal height (NHC) (42 NHC, 35 boys and 7 girls, age 12.0+/-0.5 yr, pubertal stages I-III, height between -1.3 and 1.4 SDS, height velocity standard deviation score (HVSDS)>25 degrees centile, GH peak >20 microg/l after GHRH+ARG test, mean GH concentration [mGHc]>3 microg/l) and children with organic GH deficiency (GHD) (38 GHD, 29 boys and 9 girls, age 11.2+/-3.7 yr, pubertal stages I-III, height between -5.7 and -1.3 SDS, GH peak <20 microg/l after GHRH +ARG test, mGHc <3 mg/l). Basal IGF-I levels and mGHc were also evaluated in each group over 8 nocturnal hours. IGF-I levels in FSS (209.2+/-15.6 microg/l) were similar to those in NHC (237.2+/-17.2 microg/l) and both were higher (p<0.0001) than those in GHD (72.0+/-4.0 microg/l). The GH response to GHRH +ARG test in FSS (peak: 66.4+/-5.6 microg/l) was very marked and higher (p<0.01) than that in NHC (53.3+/-4.5 microg/l) which, in turn, was higher (p<0.01) than in GHD (8.2+/-0.8 microg/l). Similarly, the mGHc in FSS was higher than in NHC (6.7+/-0.5 microg/l vs 5.1+/-0.7 microg/l, p<0.05) which, in turn, was higher than in GHD (1.5+/-0.2 microg/l, p<0.0001). In conclusion, our present study demonstrates that short children with FSS show enhancement of both basal and stimulated GH secretion but normal IGF-I levels. These findings suggest that increased somatotroph function would be devoted to maintain normal IGF-I levels thus reflecting a slight impairment of peripheral GH sensitivity in FSS.
机译：本研究的目的是评估患有家族性，特发性矮小身材（FSS）的儿童的GH状态。为了达到这个目标，我们评估了67名FSS儿童对GHRH（1 microg / kg iv）+精氨酸（ARG）（0.5 g / kg iv）的GH反应，这是最有效且可重复的促生长素分泌激发试验之一。 [50名男孩和17名女孩，年龄10.8 +/- 0.4岁，青春期I-III，身高在-3.6至-1.6标准偏差评分（SDS）之间，目标身高<10度，自发和受刺激的GH分泌均正常以及IGF-I水平]。将FSS的结果与正常身高（NHC）的儿童（42 NHC，35个男孩和7个女孩，年龄12.0 +/- 0.5岁，青春期I-III，身高介于-1.3和1.4 SDS之间的儿童）进行了比较，身高速度标准差评分（HVSDS）> 25度，GHRH + ARG测试后GH峰值> 20 microg / l，平均GH浓度[mGHc]> 3 microg / l）和患有有机GH缺乏症（GHD）的儿童（38 GHD） ，29名男孩和9名女孩，年龄11.2 +/- 3.7岁，青春期I-III，身高-5.7至-1.3 SDS，GHRH + ARG试验后GH峰值<20 microg / l，mGHc <3 mg / l） 。每组在夜间8小时内还评估了基础IGF-I水平和mGHc。 FSS（209.2 +/- 15.6 microg / l）中的IGF-I水平类似于NHC（237.2 +/- 17.2 microg / l）中的水平，两者均高于（P <0.0001）GHD中（72.0 +/-） 4.0微克/升）。 FSS（峰值：66.4 +/- 5.6 microg / l）对GHRH + ARG测试的GH反应非常显着并且比NHC（53.3 +/- 4.5 microg / l）高（p <0.01）。 ，比GHD（8.2 +/- 0.8 microg / l）高（p <0.01）。同样，FSS中的mGHc高于NHC（6.7 +/- 0.5 microg / l vs 5.1 +/- 0.7 microg / l，p <0.05），而后者又高于GHD（1.5 +/- 0.2）微克/升，p <0.0001）。总而言之，我们的研究表明，患有FSS的矮个子儿童的基础分泌和刺激性GH分泌均增强，但IGF-I水平正常。这些发现表明，增加的营养生长功能将致力于维持正常的IGF-I水平，从而反映了FSS中外周GH敏感性的轻微损害。

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