4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.

Scipione L; De-Vita D; Musella A; Flammini L; Bertoni S; Barocelli E

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.

【24h】

4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.

机译：具有抗胆碱酯酶和抗记忆删除作用的4-氨基吡啶衍生物。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.

机译：合成了几种4-氨基吡啶的氨基甲酸酯衍生物，并评估了它们的抗胆碱酯酶活性。化合物4d表现出最高的抑制作用，可阻断非竞争性乙酰胆碱酯酶和竞争性丁酰胆碱酯酶。此外，在大鼠被动回避测试中，氨基甲酸酯4d能够逆转东pol碱的记忆消除作用。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2008年第1期|共4页
作者
Scipione L; De-Vita D; Musella A; Flammini L; Bertoni S; Barocelli E;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
4-Aminopyridine; Amnesia; Animals; Avoidance Learning; Behavior; Animal; 4-氨基吡啶; 遗忘; 动物; 回避学习; 行为; 动物; 氨甲酸酯类; 胆碱酯酶抑制剂;

机译：4-Aminopyridine;Amnesia;Animals;Avoidance Learning;Behavior;Animal;4-氨基吡啶;遗忘;动物;回避学习;行为;动物;氨甲酸酯类;胆碱酯酶抑制剂;

相似文献

外文文献
中文文献
专利

1. 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity. [J] . Scipione L, De-Vita D, Musella A, Bioorganic and Medicinal Chemistry Letters . 2008,第1期

机译：具有抗胆碱酯酶和抗记忆删除作用的4-氨基吡啶衍生物。
2. Synthesis and evaluation of some new 4-aminopyridine derivatives as a potent antiamnesic and cognition enhancing drugs [J] . Saurabh K. Sinha, Sushant K. Shrivastava Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2012,第12期

机译：一些新型的4-氨基吡啶衍生物的合成和评价作为强效抗记忆和认知增强药物
3. Therapeutic potential of selanyl amide derivatives in the in vitro anticholinesterase activity and in in vivo antiamnesic action [J] . Wilhelm Ethel A., Torres Marina Laura C. P., Pereira Caroline F., Canadian Journal of Physiology and Pharmacology . 2020,第5期

机译：体外抗胆碱酯酶活性和体内抗胆碱酶活性和体内抗胆管作用的治疗潜力
4. Synthesis, characterization of some new l,3-oxazine-4-one derivatives containing 1,3,4-oxadiazole and 1,3,4-thiadiazole moiety with screening some of their biological activity. [C] . Raneen Hashim Rida, Maysoon Tariq Tawfiq International Scientific Conference on Pure Sciences, Brilliant Creativity and Renewed Building . 2019

机译：合成，表征一些含有1,3,4-二唑和1,3,4-噻二唑部分的一些新的L，3-氧嗪-4-一种衍生物，其具有筛选其一些生物活性。
5. THE HIGH-PRECISION THERMOMETRIC AND COULOMETRIC ASSAY OF PRIMARY STANDARD 4-AMINOPYRIDINE [D] . HOYLE, WILLIAM CHARLES. 1973

机译：标准4-氨基吡啶的高精度热计量和库仑分析
6. Potassium Channel Antagonists 4-Aminopyridine and the T-Butyl Carbamate Derivative of 4-Aminopyridine Improve Hind Limb Function in Chronically Non-Ambulatory Dogs; A Blinded Placebo-Controlled Trial [O] . Ji-Hey Lim, Audrey C. Muguet-Chanoit, Daniel T. Smith, -1

机译：钾通道拮抗剂4-氨基吡啶和4-氨基吡啶的氨基甲酸叔丁酯衍生物可改善非Non行犬的后肢功能；一项由安慰剂控制的盲法试验
7. Potassium channel antagonists 4-aminopyridine and the T-butyl carbamate derivative of 4-aminopyridine improve hind limb function in chronically non-ambulatory dogs; a blinded, placebo-controlled trial. [O] . Ji-Hey Lim, Audrey C Muguet-Chanoit, Daniel T Smith, 2014

机译：钾通道拮抗剂4-氨基吡啶和4-氨基吡啶的叔丁基氨基甲酸酯衍生物改善慢性非卧床犬的后肢功能;一项盲法，安慰剂对照试验。
8. Novel Tertiary Pyridostigmine Derivative 3-(N,N-Dimethylcarbamyloxy)-1-Methyl-Delta(3)-Tetrahydropyridine: Anticholinesterase Properties and Efficacy against Soman [R] . Ray, R., Clark III, O. E., Ford, K. W., 1991

机译：新型叔吡啶斯的明衍生物3-（N，N-二甲基氨基甲酰氧基）-1-甲基 - 三（3） - 四氢吡啶：抗胆碱酯酶的性质和对soman的功效

4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.

摘要

著录项

相似文献

相关主题

期刊订阅