Evolution and integration of innate immune recognition systems: the Toll-like receptors.

Takeda K

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Evolution and integration of innate immune recognition systems: the Toll-like receptors.

机译：先天免疫识别系统的进化与整合：Toll样受体。

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Toll-like receptors (TLRs) recognize specific components of micro-organisms and trigger the activation of innate immunity. TLR-mediated signaling pathways are now rapidly being elucidated. TLR signaling originates from the cytoplasmic Toll/IL-1 receptor (TIR) domain, which is conserved among all TLRs. Furthermore, TIR domain-containing adaptors, such as MyD88, TRIF, TIRAP and TRAM, play essential roles in TLR signaling. MyD88 is essential for inflammatory cytokine production via all TLRs, whereas TRIF is involved in TLR3- and TLR4-mediated MyD88-independent induction of IFN-beta. Thus, innate immunity represents a skillful system that senses microbial invasion and initiates appropriate immune responses.

机译：Toll样受体（TLR）识别微生物的特定成分并触发先天免疫的激活。 TLR介导的信号通路现在正在被迅速阐明。 TLR信号源自细胞质Toll / IL-1受体（TIR）域，该域在所有TLR之间都是保守的。此外，含TIR域的衔接子，例如MyD88，TRIF，TIRAP和TRAM，在TLR信号传导中起着重要作用。 MyD88对于通过所有TLR产生炎性细胞因子至关重要，而TRIF参与TLR3和TLR4介导的MyD88独立的IFN-β诱导。因此，先天免疫代表了一种熟练的系统，可以感知微生物入侵并启动适当的免疫反应。

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《Journal of endotoxin research》 |2005年第1期|共5页
作者
Takeda K;
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正文语种 eng
中图分类内科学;
关键词
Evolution; Immunity; Natural; Membrane Glycoproteins; Receptors; Cell Surface; 进化; 免疫; 自然; 膜糖蛋白类; 受体; 细胞表面;

机译：Evolution;Immunity;Natural;Membrane Glycoproteins;Receptors;Cell Surface;进化;免疫;自然;膜糖蛋白类;受体;细胞表面;

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1. Evolution and integration of innate immune recognition systems: the Toll-like receptors. [J] . Takeda K Journal of endotoxin research . 2005,第1期

机译：先天免疫识别系统的进化与整合：Toll样受体。
2. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. [J] . Kawai T, Akira S Nature immunology . 2010,第5期

机译：模式识别受体在先天免疫中的作用：更新Toll样受体。
3. Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors. [J] . Albiger B, Dahlberg S, Henriques-Normark B, Journal of Internal Medicine . 2007,第6期

机译：先天免疫系统在宿主抵抗细菌感染的防御中的作用：专注于Toll样受体。
4. miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling [C] . Anne M.Curtis, Luke AJ. ONeill Else Kroener-Fresenius Symposium . 2013

机译：塑造先天免疫系统的miRNA：通过Toll样受体信号传导调节
5. Activation of the innate immune response by the Alzheimer's amyloid beta protein via toll-like receptors. [D] . Udan, Maria L.D. 2009

机译：阿尔茨海默氏症淀粉样蛋白通过toll样受体激活先天免疫应答。
6. The Evolution of Parasite Recognition Genes in the Innate Immune System: Purifying Selection on Drosophila melanogaster Peptidoglycan Recognition Proteins [O] . Francis M. Jiggins, Gregory D.D. Hurst -1

机译：天然免疫系统中的寄生虫识别基因的演变：对果蝇肽聚糖聚糖识别蛋白的纯化选择。
7. Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors. [O] . Albiger, Barbara, Dahlberg, S, Henriques-Normark, B, 2007

机译：先天免疫系统在宿主防御细菌感染中的作用：关注Toll样受体。
8. Structural Basis of Pathogen Recognition by TLR Receptors of the Innate Immune System [R] . Modis, Y. 2008

机译：先天免疫系统TLR受体识别病原体的结构基础

Evolution and integration of innate immune recognition systems: the Toll-like receptors.

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