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首页> 外文期刊>Journal of environmental monitoring: JEM >Quantitative determination of hexamethylene diisocyanate(HDI),2,4-toluene diisocyanate(2,4-TDI)and 2,6-toluene diisocyanate(2,6-TDI)monomers at ppt levels in air by alkaline adduct coordination ionspray tandem mass spectrometry
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Quantitative determination of hexamethylene diisocyanate(HDI),2,4-toluene diisocyanate(2,4-TDI)and 2,6-toluene diisocyanate(2,6-TDI)monomers at ppt levels in air by alkaline adduct coordination ionspray tandem mass spectrometry

机译：碱性加合物配位离子喷雾串联质谱法测定空气中ppt级的六亚甲基二异氰酸酯（HDI），2,4-甲苯二异氰酸酯（2,4-TDI）和2,6-甲苯二异氰酸酯（2,6-TDI）单体

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Occupational exposures to isocyanates can lead to occupational asthma.Once sensitized,some workers could react to isocyanate monomers at concentrations below 1 % of the Permissible Exposure Limit of 5 ppb in air.Currently available methods are not sufficiently sensitive to adequately evaluate isocyanates present at these levels in workplace air.This article describes a novel method for isocyanate determination allowing the ultratrace quantification in workplace air of hexamethylene diisocyanate,2,4-toluene diisocyanate and 2,6-toluene diisocyanate monomers.Sampling is performed during a complete workshift at a flow rate of 1 L min~(-1)with a cassette containing a l-(2-methoxyphenyl)piperazine-impregnated 25 mm filter.Analysis is performed using liquid chromatography hyphenated with coordination ionspray tandem mass spectrometry.The analytical method's linearity was measured for a concentration range varying from the limit of detection of 0.04-0.13 ng mL~(-1),depending on the monomer,up to approximately 32 ng mL~(-1)for every isocyanate monomer,all with correlation coefficients(R2)greater than 0.999.The analytical method's lower limit of quantification combined with an adapted sampling strategy allow the quantification of isocyanate monomers down to 0.04 ppt for an 8 h work shift when a lithium adduct is used,which is more than 300 times lower than the most sensitive method currently available.This novel method can be used to confirm the very low level of isocyanate monomers for the safe reassignment of sensitized workers and it is also useful for charting the isocyanate dispersion tail in workplace environments.
机译：职业暴露于异氰酸酯会导致职业性哮喘。一旦过敏，一些工人会与空气中5 ppb的允许暴露极限的1％以下的异氰酸酯单体发生反应。本文介绍了一种测定异氰酸酯的新方法，该方法可以在工作场所空气中超痕量定量六亚甲基二异氰酸酯，2,4-甲苯二异氰酸酯和2,6-甲苯二异氰酸酯单体。用含1-（2-甲氧基苯基）哌嗪浸渍的25 mm滤膜的滤盒，以1 L min〜（-1）的流速进行分析。使用配位离子喷雾串联质谱联用的液相色谱法进行分析。测量分析方法的线性浓度范围从0.04-0.13 ng mL〜（-1）的检测极限变化，取决于单体每种异氰酸酯单体的最大吸附量约为32 ng mL〜（-1），相关系数（R2）均大于0.999。分析方法的定量下限与合适的采样策略相结合，可将低至0.04 ppt的异氰酸酯单体定量使用锂加合物时的工作班次为8小时，这比目前最敏感的方法低300倍。此新方法可用于确认异氰酸酯单体的含量非常低，以安全地重新分配敏感的工人它对于在工作场所环境中绘制异氰酸酯分散体尾部也很有用。

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