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首页> 外文期刊>Journal of epidemiology / >Associations between polymorphisms in the glucocorticoid-receptor gene and cardiovascular risk factors in a chinese population
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Associations between polymorphisms in the glucocorticoid-receptor gene and cardiovascular risk factors in a chinese population

机译：糖皮质激素受体基因多态性与中国人群心血管危险因素的关系

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Background: Glucocorticoid is an important regulator of energy homeostasis. Glucocorticoid receptor (GR) gene polymorphisms that contribute to variability in glucocorticoid sensitivity have been identified. We explored the associations of single-nucleotide polymorphisms (SNPs) of the GR gene with traditional cardiovascular risk factors in the Chinese Han population. Methods: We recruited 762 consecutive adults who underwent a regular physical examination at Beijing Xuanwu Hospital. Blood pressure, glucose, lipid levels (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides), body mass index (BMI), and waist-to-hip ratio were measured. Fourteen tag SNPs and 5 functional SNPs were selected and genotyped using the high-throughput Sequenom genotyping platform. Differences between genotypes/alleles for each SNP were adjusted for sex and age and tested using a general linear model procedure. Various models of inheritance, including additive, dominant, and recessive, were tested. Results: Among the 19 SNPs examined, 5 markers were associated with cardiovascular risk factors. The rs41423247 GG genotype and the rs7701443 AA genotype were associated with higher BMI and systolic blood pressure (P < 0.0004), and the rs17209251 GG genotype was associated with higher systolic blood pressure (P < 0.0004). Lower systolic blood pressure, total cholesterol, and LDL cholesterol were observed among rs10052957 A allele carriers (P < 0.0004), and lower plasma glucose and LDL-cholesterol concentrations were observed among rs2963156 TT carriers (P < 0.0004). Conclusions: Polymorphism of the GR gene was associated with cardiovascular risk factors and may contribute to susceptibility to cardiovascular disease.
机译：背景：糖皮质激素是能量稳态的重要调节剂。糖皮质激素受体（GR）基因多态性已被确定有助于糖皮质激素敏感性的变化。我们探讨了中国汉族人群中GR基因的单核苷酸多态性（SNPs）与传统心血管危险因素的关系。方法：我们招募了762名连续的成年人，他们在北京宣武医院接受了定期的身体检查。测量血压，葡萄糖，脂质水平（总胆固醇，高密度脂蛋白胆固醇，低密度脂蛋白[LDL]胆固醇和甘油三酸酯），体重指数（BMI）和腰臀比。选择了14个标签SNP和5个功能性SNP，并使用高通量Sequenom基因分型平台进行基因分型。调整每个SNP的基因型/等位基因之间的差异，以区分性别和年龄，并使用一般的线性模型程序进行测试。测试了各种继承模型，包括加性，显性和隐性。结果：在检查的19个SNP中，有5个标志物与心血管危险因素有关。 rs41423247 GG基因型和rs7701443 AA基因型与较高的BMI和收缩压相关（P <0.0004），而rs17209251 GG基因型与较高的收缩压相关（P <0.0004）。在rs10052957 A等位基因携带者中观察到较低的收缩压，总胆固醇和LDL胆固醇（P <0.0004），在rs2963156 TT携带者中观察到较低的血浆葡萄糖和LDL-胆固醇浓度（P <0.0004）。结论：GR基因的多态性与心血管危险因素有关，可能对心血管疾病易感性。

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