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首页> 外文期刊>Journal of experimental & clinical cancer research : >Alleviation of cyclophosphamide-induced urotoxicity by naturally occurring sulphur compounds.
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Alleviation of cyclophosphamide-induced urotoxicity by naturally occurring sulphur compounds.

机译：天然存在的硫化合物减轻环磷酰胺引起的尿毒症。

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Treatment of Swiss albino mice with naturally occurring sulphur compounds such as Diallyl sulphide (DAS) (500 microg/dose/animal, i.p) and Diallyl Disulphide (DADS) (250 microg/dose/animal, i.p) for five days along with cyclophosphamide (CTX) (1.5 mmol/kg.body.wt; i.p) reduced the CTX induced urotoxicity. Morphological analysis of the urinary bladders of the CTX treated group showed severe inflammation and dark colouration whereas the sulphur compounds treated group showed almost normal bladder morphology. Treatment with DAS and DADS was found to reduce the urine urea N2 level DAS (15.31+/-0.01 g/l), DADS (12.38+/-0.17 g/l) 4 hrs after CTX administration which was elevated in the CTX alone treated group (26.87+/-1.86 g/l). Urine protein level, which was enhanced drastically (8.66+/-0.47 g/l) after the CTX treatment, was significantly reduced (2.9+/-0.25 g/l) by the treatment with DADS. Similarly GSH content (which was drastically reduced by the CTX administration) in both bladder (0.87+/-0.1 nmol/mg protein) and liver (2.47+/-0.6 nmol/mg protein) was enhanced significantly (P<0.001) by the treatment with DAS and DADS both in bladder (DAS--1.56+/-0.17 nmol/mg protein; DADS--2.65+/-0.21 nmol/mg protein) and liver (DAS--5.30+/-0.07 nmol/mg protein; DADS--6.93+/-0.06 nmol/mg protein). Histopathological analysis of the bladder of the CTX alone treated group showed severe necrosis of the tissue whereas the sulphur compounds treated group showed normal bladder pathology.
机译：用天然存在的硫化合物（如二烯丙基硫（DAS）（500微克/剂量/动物，腹腔注射）和二烯丙基二硫化物（DADS）（250微克/剂量/动物，腹腔注射）以及环磷酰胺（自然）处理瑞士白化病小鼠五天CTX）（1.5 mmol / kg.body.wt; ip）降低了CTX诱导的尿毒症。 CTX治疗组的膀胱形态学分析显示严重炎症和深色，而硫化合物治疗组则显示几乎正常的膀胱形态。发现用DAS和DADS处理可降低CTX给药后4小时的尿素尿N2水平DAS（15.31 +/- 0.01 g / l），DADS（12.38 +/- 0.17 g / l），这在单独治疗的CTX中升高组（26.87 +/- 1.86 g / l）。 CTX处理后尿蛋白水平显着提高（8.66 +/- 0.47 g / l），而DADS处理显着降低了尿蛋白水平（2.9 +/- 0.25 g / l）。同样，膀胱（0.87 +/- 0.1 nmol / mg蛋白质）和肝脏（2.47 +/- 0.6 nmol / mg蛋白质）中的GSH含量（通过CTX给药大大降低）也显着提高（P <0.001）。膀胱（DAS--1.56 +/- 0.17 nmol / mg蛋白质; DADS--2.65 +/- 0.21 nmol / mg蛋白质）和肝脏（DAS--5.30 +/- 0.07 nmol / mg蛋白质）的DAS和DADS治疗; DADS--6.93 +/- 0.06 nmol / mg蛋白）。仅CTX治疗组的膀胱的组织病理学分析显示组织严重坏死，而硫化合物治疗组显示正常的膀胱病理。

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