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首页> 外文期刊>Journal of Experimental Botany >Towards understanding the virulence functions of RXLR effectors of the oomycete plant pathogen Phytophthora infestans.
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Towards understanding the virulence functions of RXLR effectors of the oomycete plant pathogen Phytophthora infestans.

机译：旨在了解卵菌植物致病疫霉菌RXRX效应子的毒力功能。

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摘要

Plant pathogens establish infection by secretion of effector proteins that may be delivered inside host cells to manipulate innate immunity. It is increasingly apparent that the ubiquitin proteasome system (UPS) contributes significantly to the regulation of plant defences and, as such, is a target for pathogen effectors. Bacterial effectors delivered by the type III and IV secretion systems have been shown to interact with components of the host UPS. Some of these effectors possess functional domains that are conserved in UPS enzymes, whilst others contain novel domains with ubiquitination activities. Relatively little is known about effector activities in eukaryotic microbial plant pathogens. Nevertheless, effectors from oomycetes that contain an RXLR motif for translocation to the inside of plant cells have been shown to suppress host defences. Annotation of the genome of one such oomycete, the potato late blight pathogen Phytophthora infestans, and protein-protein interaction assays to discover host proteins targeted by the RXLR effector AVR3a, have revealed that this eukaryotic plant pathogen also has the potential to manipulate host plant UPS functions.
机译：植物病原体通过分泌效应蛋白来建立感染，效应蛋白可以在宿主细胞内传递以操纵先天免疫。越来越明显的是，泛素蛋白酶体系统（UPS）极大地促进了植物防御的调控，因此，它是病原体效应子的目标。 III型和IV型分泌系统传递的细菌效应子已显示与宿主UPS的组件相互作用。这些效应子中的一些具有在UPS酶中保守的功能域，而另一些包含具有泛素化活性的新域。关于真核微生物植物病原体中效应子活性的了解相对较少。然而，已经证明来自卵菌的含有RXLR基序的效应子可以移位到植物细胞内部，该效应抑制宿主防御。一种这样的卵菌（马铃薯晚疫病病原菌疫霉菌）的基因组注释，以及蛋白质-蛋白质相互作用测定法发现了RXLR效应子AVR3a靶向的宿主蛋白质，这些真核植物病原体也具有操纵宿主植物UPS的潜力。功能。

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