Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.

Wang WL; Yao DY; Gu M; Fan MZ; Li JY; Xing YC; Nan FJ

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Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.

机译：作为潜在的抗流感病毒药物的新型含双环杂环化合物的合成和生物学评估。

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摘要

A series of novel 4,2-bisheterocycle tandem derivatives consisting of a methyloxazole and thiazole subunit were synthesized. Many compounds were found to inhibit human influenza A virus. Several analogues exhibited moderate biological activity and could serve as leads for further optimizations for antivirus research.

机译：合成了一系列新颖的由甲基恶唑和噻唑亚基组成的4，2-双环杂环串联衍生物。发现许多化合物可抑制人类甲型流感病毒。几种类似物表现出中等的生物学活性，可作为进一步优化抗病毒研究的线索。

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《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共4页
作者
Wang WL; Yao DY; Gu M; Fan MZ; Li JY; Xing YC; Nan FJ;
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正文语种 eng
中图分类基础医学;
关键词
novel; Virus; Influenza; Synthesis; Evaluation; 流感;

机译：novel;Virus;Influenza;Synthesis;Evaluation;流感;

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2. Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents. [J] . Wang WL, Yao DY, Gu M, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

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Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.

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