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首页> 外文期刊>Journal of Equine Veterinary Science >Serum concentrations of lidocaine and its metabolites MEGX and GX during and after prolonged intravenous infusion of lidocaine in horses after colic surgery.
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Serum concentrations of lidocaine and its metabolites MEGX and GX during and after prolonged intravenous infusion of lidocaine in horses after colic surgery.

机译：绞痛术后长时间静脉输注利多卡因期间和之后，利多卡因及其代谢产物MEGX和GX的血清浓度。

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摘要

Lidocaine is the most commonly used prokinetic after gastrointestinal surgery in horses. Cardiovascular status, hepatic function, and duration of therapy are the primary determinants of lidocaine metabolism, and these factors could affect equine patients after colic surgery. This study examined the systemic concentrations of lidocaine and its active metabolites monoethylglycinexylidide (MEGX) and glycinexylidide (GX), in horses that had undergone colic surgery and subsequently received prolonged postoperative lidocaine infusions. The mean lidocaine concentration increased over the course of treatment but did not exceed the therapeutic range. Concentrations of MEGX and GX increased progressively, and concentrations exceeding 1,000 ng/ml were observed frequently after 72 hours of infusion. None of the horses in the study developed severe signs of toxicity; however, the progressively increasing concentrations of lidocaine, MEGX, and GX are cause for concern in clinically ill patients receiving prolonged lidocaine therapy. The potential contribution of MEGX and GX should be considered when evaluating adverse reactions to prolonged lidocaine infusions.
机译：利多卡因是马胃肠道手术后最常用的促运动药物。心血管状况，肝功能和治疗时间是利多卡因代谢的主要决定因素，这些因素可能会在绞痛手术后影响马匹患者。这项研究检查了接受绞痛手术并随后接受延长的术后利多卡因输注的马匹中利多卡因及其活性代谢物单乙基甘氨糖苷（MEGX）和甘氨糖苷（GX）的全身浓度。平均利多卡因浓度在治疗过程中增加，但未超过治疗范围。输注72小时后，MEGX和GX的浓度逐渐增加，并且经常观察到浓度超过1,000 ng / ml。研究中没有马出现严重的中毒迹象。但是，利多卡因，MEGX和GX的浓度逐渐增加，引起接受长期利多卡因治疗的临床疾病患者的关注。在评估长期服用利多卡因输注的不良反应时，应考虑MEGX和GX的潜在作用。

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