1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.

Cecchetti V; Schiaffella F; Tabarrini O; Fravolini A

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1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.

机译：1,4-苯并噻嗪基氧基）烷基哌嗪衍生物可作为潜在的降压药。

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摘要

A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.

机译：合成了具有与苯并噻嗪核不同地连接的哌嗪部分的一系列化合物，并通过放射性配体受体结合测定评估了它们的体外α-肾上腺素受体亲和力。一些带有氧烷基-（2-甲氧基苯基）哌嗪侧链的化合物是良好的α1-肾上腺素受体配体。

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《Bioorganic and Medicinal Chemistry Letters》 |2000年第5期|共4页
作者
Cecchetti V; Schiaffella F; Tabarrini O; Fravolini A;
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正文语种 eng
中图分类药学;生物化学;
关键词
Antihypertensive Agents; Piperazines; Thiazines; Adrenergic beta-Antagonists; 抗高血压药; 哌嗪类; 噻嗪类;

机译：Antihypertensive Agents;Piperazines;Thiazines;Adrenergic beta-Antagonists;抗高血压药;哌嗪类;噻嗪类;

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1. 1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents. [J] . Cecchetti V, Schiaffella F, Tabarrini O, Bioorganic and Medicinal Chemistry Letters . 2000,第5期

机译：1,4-苯并噻嗪基氧基）烷基哌嗪衍生物可作为潜在的降压药。
2. Naphtho(2,3-b)(1,4)-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. [J] . Tandon VK, Maurya HK, Yadav DB, Bioorganic and Medicinal Chemistry Letters . 2006,第22期

机译：萘并（2,3-b）（1,4）-噻嗪-5,10-二酮和3-取代的1,4-二氧代-1,4-二氢萘-2-基-硫代链烷酸酯衍生物：合成和生物学评价为潜在的抗菌和抗真菌剂。
3. Synthesis of new functionalized 3-substituted (1,2,4)triazolo (4,3-a)pyrimidine derivatives: potential antihypertensive agents. [J] . Ali KA, Ragab EA, Farghaly TA, Acta Poloniae Pharmaceutica: Durg Research . 2011,第2期

机译：合成新的功能化的3-取代的（1,2,4）三唑（4,3-a）嘧啶衍生物：潜在的降压药。
4. Synthesis and toxicological activity of 5-nitroindazole sulfonamides derivatives as potential antimicrobial agents. Optimization of the synthesis [C] . Corina Cheptea, Andreea-Celia Benchea, Marius Găină, 2017 E-Health and Bioengineering Conference . 2017

机译：5-硝基吲唑磺酰胺衍生物作为潜在抗菌剂的合成及其毒理活性。优化合成
5. Ab initio Prediction of Reduction Potentials of Pharmaceutically Relevant 3-Aryl-Quinoxaline-2-carbonitrile 1,4-di-N-oxide Derivatives [D] . Miller, Eric M. 2018

机译：AB Initio对药学相关的3-芳基 - 喹喔啉-2-腈1,4-Di-N-氧化物衍生物的降低电位的预测
6. Aminosugar derivatives as potential anti-human immunodeficiency virus agents. [O] . A Karpas, G W Fleet, R A Dwek, 1988

机译：氨基糖衍生物可作为潜在的抗人免疫缺陷病毒制剂。
7. New antihypertensive agents. I. Synthesis and antihypertensive activity of some 4-piperidylbenzimidazolinone derivatives. [O] . HIROYUKI OBASE, NOBUHIRO NAKAMIZO, HARUKI TAKAI, 1982

机译：新的抗高血压剂。 I.一些4-哌啶基苯齐咪唑啉酮衍生物的合成和抗高血压活性。

1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.

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