Synthesis and structure-activity relationship(SAR)of novel perfluoroalkyl-containing quaternary ammonium salts

Jian-Ying Sun; Jing Li; Xiao-Long Qiu; Feng-Ling Qing

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Synthesis and structure-activity relationship(SAR)of novel perfluoroalkyl-containing quaternary ammonium salts

机译：新型含全氟烷基的季铵盐的合成及构效关系（SAR）

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A new series of perfluoroalkyl-containing quaternary ammonium compounds were prepared and examined for their antibacterial activities.The perfluoroalkyl-containing quaternary ammonium salts mainly exhibited excellent antibacterial activity for the Gram-positive strain such as Staphylococcus aureus,the MIC(minimal inhibitory concentration)values was between 2.5 and 10 mug/mL and the MBC(minimal bactericidal concentration)values were 20 mug/mL.They all showed weak activity against the Gram-negative strain such as Escherichia coli,and against fungi such as Candida albicans,the MIC values and MBC values were about 100mug/mL.Moreover,the relationship between their antimicrobial activities and structures were further discussed.

机译：制备了一系列新的含全氟烷基的季铵盐化合物，并对其抗菌性能进行了研究。在2.5和10杯/毫升之间，最低杀菌浓度（MBC）值为20杯/毫升。它们对革兰氏阴性菌株（如大肠杆菌）和真菌（如白色念珠菌）均显示弱活性，MIC值MBC值约为100mug / mL。此外，还讨论了它们的抗菌活性与结构之间的关系。

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来源
《Journal of Fluorine Chemistry》 |2005年第10期|共7页
作者
Jian-Ying Sun; Jing Li; Xiao-Long Qiu; Feng-Ling Qing;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Perfluoroalkyl-containing compounds; Quaternary ammonium salt; Antibacterial activity;

机译：含全氟烷基的化合物;季铵盐;抗菌活性;

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1. Synthesis and structure-activity relationship(SAR)of novel perfluoroalkyl-containing quaternary ammonium salts [J] . Jian-Ying Sun, Jing Li, Xiao-Long Qiu, Journal of Fluorine Chemistry . 2005,第9a10期

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2. Polymeric quaternary ammonium salt activity against Fusarium oxysporum f. sp cubense race 4: Synthesis, structure-activity relationship and mode of action [J] . Huang Zhenfeng, Liuyang Runqi, Dong Chengyun, Reactive & Functional Polymers . 2017,第MAY期

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6. Anti-SARS-CoV-2 Activity of Surgical Masks Infused with Quaternary Ammonium Salts [O] . Gary S. Selwyn, Chunyan Ye, Steven B. Bradfute 2021

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7. Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with hydroxylated alicyclic or aliphatic amines. [O] . YONG SUP LEE, JAE YEOL LEE, SUN HO JUNG, 1994

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Synthesis and structure-activity relationship(SAR)of novel perfluoroalkyl-containing quaternary ammonium salts

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