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首页> 外文期刊>Journal of Food Science and Technology >Dietary coconut kernel protein beneficially modulates NF kappa B and RAGE expression in streptozotocin induced diabetes in rats
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Dietary coconut kernel protein beneficially modulates NF kappa B and RAGE expression in streptozotocin induced diabetes in rats

机译：日粮椰子仁蛋白可有效调节链脲佐菌素诱导的糖尿病大鼠的NFκB和RAGE表达

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Previous studies showed that arginine rich coconut kernel protein (CKP) maintains glucose homeostasis in experimental diabetic rats. But the mechanism of this effect was not clear. This study investigated the effect of CKP on the expression of liver receptor for advance glycated end products (RAGE), inducible nitric oxide synthase (iNOS) and NFkB. Diabetes was induced by injecting a single dose of streptozotocin (75 mg/kg body weight) intraperitoneally. After inducing diabetes, CKP was administered to rats orally for 45 days. After the experimental period, serum glucose, insulin, liver glycogen, glucose metabolizing enzyme activities and the expression of liver RAGE, iNOS and NFkB was evaluated. The results showed that CKP beneficially modulated the levels of glucose and insulin as well as the metabolizing enzyme activities. Expression of RAGE and NFkB was found to be over expressed in diabetic rats but was found to be down regulated in CKP fed diabetic rats. iNOS expression was down regulated in diabetic rats, which was expressed normally in CKP fed diabetic rats. These results clearly demonstrated that anti diabetic activity of CKP is mediated through NFkB pathway.
机译：先前的研究表明，富含精氨酸的椰子仁蛋白（CKP）在实验性糖尿病大鼠中维持葡萄糖稳态。但是这种作用的机理尚不清楚。这项研究调查了CKP对晚期糖基化终末产物（RAGE），诱导型一氧化氮合酶（iNOS）和NFkB肝受体表达的影响。腹膜内注射单剂量链脲佐菌素（75 mg / kg体重）可诱发糖尿病。诱发糖尿病后，将CKP口服给予大鼠45天。实验期后，评估血清葡萄糖，胰岛素，肝糖原，葡萄糖代谢酶活性以及肝RAGE，iNOS和NFkB的表达。结果表明，CKP有益地调节了葡萄糖和胰岛素的水平以及代谢酶的活性。发现在糖尿病大鼠中RAGE和NFkB的表达过表达，但是在以CKP喂养的糖尿病大鼠中发现RAGE和NFkB的表达下调。 iNOS表达在糖尿病大鼠中被下调，这在以CKP喂养的糖尿病大鼠中正常表达。这些结果清楚地表明，CKP的抗糖尿病活性是通过NFkB途径介导的。

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