The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.

Cathers BE; Schloss JV

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The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.

机译：磺酰亚胺酰胺是天冬氨酸和金属蛋白酶的新型过渡态类似物。

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We have developed a novel strategy for the preparation of tetrahedral transition state analogs for aspartic acid and metallo-proteases based upon the sulfonimidamide functional group. Our best alpha-des-amino dipeptide analog binds at least 100-fold tighter than the corresponding ground state structure (i.e., amide). A previously unpublished five-membered cyclic sulfonimidamide was also synthesized.

机译：我们已经开发了一种新的策略，用于基于磺酰胺基酰胺官能团制备天冬氨酸和金属蛋白酶的四面体过渡态类似物。我们最好的α-des-氨基二肽类似物与相应的基态结构（即酰胺）的结合至少紧密100倍。还合成了以前未公开的五元环亚磺酰胺。

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《Bioorganic and Medicinal Chemistry Letters》 |1999年第11期|共6页
作者
Cathers BE; Schloss JV;
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正文语种 eng
中图分类药学;生物化学;
关键词
Aspartic Acid; Metalloproteinases; Sulfonamides; Carboxypeptidases; carboxypeptidase A; 天冬氨酸; 金属蛋白酶类; 磺胺类;

机译：Aspartic Acid;Metalloproteinases;Sulfonamides;Carboxypeptidases;carboxypeptidase A;天冬氨酸;金属蛋白酶类;磺胺类;

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1. The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases. [J] . Cathers BE, Schloss JV Bioorganic and Medicinal Chemistry Letters . 1999,第11期

机译：磺酰亚胺酰胺是天冬氨酸和金属蛋白酶的新型过渡态类似物。
2. alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. [J] . Orrling KM, Marzahn MR, Gutierrez de Teran H Bioorganic and medicinal chemistry . 2009,第16期

机译：α取代的norstatines作为多种消化液空肠疟疾天冬氨酸蛋白酶抑制剂的过渡态模拟物。
3. Acetyl-(D) Arginyl - Glycyl- (D) Aspartic Acid Is A Better Integrin Binding Analog Than Acetyl - Arginyl - Glycyl-Aspartic Acid In Membrane Mimicking Solvents. [J] . Samir Kumar Nath, Ashish Research Journal of Pharmaceutical, Biological and Chemical Sciences . 2015,第1期

机译：在膜模拟溶剂中，乙酰基-（D）精氨酰基-甘氨酰-（D）天冬氨酸比乙酰基-精氨酸-甘氨酰-天冬氨酸是一种更好的整联蛋白结合类似物。
4. ENANTIOSELECTIVE REDUCTION FROM QUATERNARY COPPER D,L AMINO ACID COMPLEXES: ORIGIN OF THE WEAK CHIRAL EFFECT OBSERVED WITH D/L ASPARTIC AND GLUTAMIC ACIDS [C] . Jean-Claude Tabet International Mass Spectrometry Conference . 2018

机译：从季铜D，L氨基酸复合物的对映选择性减少：用D / L天冬氨酸和谷氨酸观察到弱手性效应的来源
5. Fluorine nuclear magnetic resonance studies of biological systems: Part~1. Investigation of the binding of a fluorinated boronic acid transition state analog to alpha-chymotrypsin. Part~2. Fluorine NMR study of the metabolism of m-trifluoromethyl-alpha-ethyl benzhydrol (flumecinol). [D] . Sylvia, L. Ann. 1992

机译：生物系统的氟核磁共振研究：第1部分。研究氟化硼酸过渡态类似物与α-胰凝乳蛋白酶的结合。第二部分氟NMR研究间三氟甲基-α-乙基苯甲酚（氟美西诺）的代谢。
6. Effects of asparagine mutagenesis of conserved aspartic acids in helix two (D2.50) and three (D3.32) of M1 – M4 muscarinic receptors on the irreversible binding of nitrogen mustard analogs of acetylcholine and McN-A-343 [O] . Hinako Suga, Frederick J. Ehlert -1

机译：M1-M4毒蕈碱受体的两个螺旋（D2.50）和三个螺旋（D3.32）中天冬氨酸的保守天冬氨酸诱变对不可逆结合的乙酰胆碱氮芥子类似物和McN-A-343的影响
7. Effects of Asparagine Mutagenesis of Conserved Aspartic Acids in Helix 2 (D2.50) and 3 (D3.32) of M1–M4Muscarinic Receptors on the Irreversible Binding of Nitrogen Mustard Analogs of Acetylcholine and McN-A-343 [O] . Hinako Suga, Frederick J. Ehlert 2013

机译：M1-M4muscarinic受体螺旋2（D2.50）和3（D3.32）螺旋2（D2.50）和3（D3.32）对乙酰胆碱和MCN-A-343的氮芥菜类似物的不可逆结合的影响

The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.

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