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首页> 外文期刊>Journal of genetic counseling >Reading between the lines: A comparison of responders and non-responders to a family history questionnaire and implications for cancer genetic counselling
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Reading between the lines: A comparison of responders and non-responders to a family history questionnaire and implications for cancer genetic counselling

机译：字里行间：家庭史调查表中应答者和非应答者的比较及其对癌症遗传咨询的意义

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Family history questionnaires (FHQ) are useful tools for cancer genetic counseling, providing an informational basis for pedigree construction and individualized cancer risk assessment. Reported return rates of mailed FHQs amongst familial cancer clinics that utilize them are lower than desired however, and it is unknown whether patients perceive required completion of a FHQ as a barrier to access of cancer genetics services. This study critically evaluated the use of a mailed FHQ for all routine new patient referrals to a single hereditary cancer clinic in Quebec, Canada. Reasons for responseon-response to a FHQ and the effect of administration of a questionnaire on patients' self-reported level of motivation to pursue genetic counseling, were examined. Of 112 eligible individuals referred during the study period, 86 completed a semistructured telephone survey; of these, 45% had returned the mailed FHQ prior to the telephone survey (Responders) and 55% had not (Non-responders). Overall, the majority of participants indicated a FHQ is an acceptable and understandable method of collecting family history information. Most prevalent reasons for not returning the FHQ were (bad) timing (56%), and difficulty accessing family history information (46%). Non-response was significantly associated with difficulty in asking relatives for the requested information (p=0.011), and Non-responders cited fewer overall perceived benefits of cancer genetic counseling as compared with Responders (p<0.0001). One quarter of Non-responders returned the mailed FHQ following administration of the telephone survey, suggesting implementation of a follow-up prompt is a cost-effective way to increase response.
机译：家族史调查表（FHQ）是进行癌症遗传咨询的有用工具，为谱系构建和个体化的癌症风险评估提供了信息基础。然而，在利用FHQ的家族癌症诊所中，邮寄的FHQ的回报率低于期望值，而且尚不清楚患者是否认为需要完成FHQ是获得癌症遗传服务的障碍。这项研究严格评估了邮寄FHQ在所有常规新患者转诊至加拿大魁北克一家遗传性癌症诊所时的使用。研究了对FHQ有反应/无反应的原因以及问卷调查对患者自我报告的寻求基因咨询的动机水平的影响。在研究期间，在112位合格的个人中，有86位完成了半结构电话调查;其中，有45％的人在电话调查之前已退回已寄出的FHQ（答复者），而55％的未寄回（未答复）。总体而言，大多数参与者表示，FHQ是一种收集家族史信息的可接受且可理解的方法。不返回FHQ的最普遍原因是（糟糕的）时机（56％）和难以获得家族史信息（46％）。无应答者与向亲属询问所要求的信息的难度显着相关（p = 0.011），并且无应答者引用的癌症遗传咨询的总体感知受益要少于应答者（p <0.0001）。在进行电话调查后，四分之一的未答复者退回了已邮寄的FHQ，这表明实施跟进提示是增加答复的一种经济有效的方法。

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