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首页> 外文期刊>Journal of genetics >Nucleotide composition bias and codon usage trends of gene populations in Mycoplasma capricolum subsp capricolum and M. agalactiae
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Nucleotide composition bias and codon usage trends of gene populations in Mycoplasma capricolum subsp capricolum and M. agalactiae

机译：山羊支原体亚种，无乳分枝杆菌中基因组成的核苷酸组成偏倚和密码子使用趋势

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摘要

Because of the low GC content of the gene population, amino acids of the two mycoplasmas tend to be encoded by synonymous codons with an A or T end. Compared with the codon usage of ovine, Mycoplasma capricolum and M. agalactiae tend to select optimal codons, which are rare codons in ovine. Due to codon usage pattern caused by genes with key biological functions, the overall codon usage trends represent a certain evolutionary direction in the life cycle of the two mycoplasmas. The overall codon usage trends of a gene population of M. capricolum subsp. capricolum can be obviously separated from other mycoplasmas, and the overall codon usage trends of M. agalactiae are highly similar to those of M. bovis. These results partly indicate the independent evolution of the two mycoplasmas without the limits of the host cell's environment. The GC and AT skews estimate nucleotide composition bias at different positions of nucleotide triplets and the protein consideration caused by the nucleotide composition bias at codon positions 1 and 2 largely take part in synonymous codon usage patterns of the two mycoplasmas. The correlation between the codon adaptation index and codon usage variation indicates that the effect of codon usage on gene expression in M. capricolum subsp. capricolum is opposite to that of M. agalactiae, further suggesting independence of the evolutionary process influencing the overall codon usage trends of gene populations of mycoplasmas.
机译：由于基因群体的GC含量低，两个支原体的氨基酸倾向于由A或T端的同义密码子编码。与绵羊的密码子使用相比，支原体和无乳支原体倾向于选择最佳密码子，这是绵羊中稀有的密码子。由于具有关键生物学功能的基因引起的密码子使用方式，总体密码子使用趋势代表了两种支原体生命周期中的某个进化方向。 M. capricolum亚种的基因群体的总体密码子使用趋势。癸ric可以明显地与其他支原体分开，无乳志贺氏菌的总体密码子使用趋势与牛分枝杆菌高度相似。这些结果部分表明了两种支原体的独立进化，而不受宿主细胞环境的限制。 GC和AT偏斜估计核苷酸三联体在不同位置的核苷酸组成偏倚，并且由密码子位置1和2的核苷酸组成偏倚引起的蛋白质考虑在很大程度上参与了两个支原体的同义密码子使用模式。密码子适应指数与密码子使用变化之间的相关性表明密码子使用对Capricolum subsp。基因表达的影响。癸ric与无乳分枝杆菌相反，进一步表明进化过程的独立性会影响支原体基因群体的总体密码子使用趋势。

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