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首页> 外文期刊>Journal of genetics >Intersex (ix) mutations of Drosophila melanogaster cause nonrandom cell death in genital disc and can induce tumours in genitals in response to decapentaplegic (dpp(disk)) mutations
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Intersex (ix) mutations of Drosophila melanogaster cause nonrandom cell death in genital disc and can induce tumours in genitals in response to decapentaplegic (dpp(disk)) mutations

机译：果蝇的双性（ix）突变导致生殖器圆盘中非随机性细胞死亡，并因去能力障碍（dpp（disk））突变而诱发生殖器中的肿瘤

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In Drosophila melanogaster, the intersex (ix) is a terminally positioned gene in somatic sex determination hierarchy and function with the female specific product of double sex (DSXF) to implement female sexual differentiation. The null phenotype of ix is to transform diplo-X individuals into intersexes while leaving haplo-X animals unaffected. This study on the effect of different intersex mutations on genital disc development provides the following major results: (i) similar range of a characteristic array of morphological structures (from almost double sex terminalia to extreme reduction of terminal appendages) was displayed by the terminalia of XX ix(1)/ix(1), XX ix(2)/ix(2) and XX ix(5)/ix(5) individuals; (ii) an increased number of apoptotic cells were found to occur in a localized manner in mature third instar larval genital discs of ix individuals; (iii) ix mutations can induce high frequency of neoplastic tumours in genitals in the presence of decapentaplegic (dpp(disk)) mutations; and (iv) heteroallelic combinations of dpp(disk) mutations can also induce tumours in intersex genitals with variable expressivity. On the basis of these findings, we suggest that: (i) loss of function of ix causes massive cell death in both male and female genital primordia of genital discs, resulting phenotype mimicking in male and female characteristics in genitals; and (ii) at the discs, the apoptotic cells persist as undead' cells that can induce oncogenic transformation in the neighbouring disc cells when dpp signalling is blocked or reduced by dpp(disk) mutations.
机译：在果蝇（Drosophila melanogaster）中，双性恋（ix）是体细胞性别决定体系中的末端定位基因，具有雌性双性产物（DSXF）的功能，可以实现雌性分化。 ix的无效表型是在不影响haplo-X动物的情况下将diplo-X个体转化为双性恋。这项关于不同性间突变对生殖器椎间盘发育影响的研究提供了以下主要结果：（i）的终末期显示了相似范围的形态结构特征阵列（从几乎双重性终末期到终末附肢极度减少）。 XX ix（1）/ ix（1），XX ix（2）/ ix（2）和XX ix（5）/ ix（5）个人; （ii）发现在ix个个体的成熟的三龄幼虫生殖器盘中以局部方式发生的凋亡细胞数量增加; （iii）ix突变可以在存在十足功能不全（dpp（disk））突变的情况下在生殖器中诱发高频率的肿瘤性肿瘤; （d）dpp（disk）突变的异源等位基因组合也可以在雌雄异体生殖器中诱导可变表达的肿瘤。根据这些发现，我们建议：（i）ix功能的丧失会导致生殖器圆盘的男性和女性生殖器原基中大量细胞死亡，从而导致生殖器的男性和女性特征表型模仿; （ii）在圆盘处，凋亡细胞以不死细胞的形式持续存在，当dpp信号被dpp（圆盘）突变阻止或减少时，可诱导邻近圆盘细胞发生致癌转化。

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