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首页> 外文期刊>Journal of geriatric oncology >Age, sex and gender impact multidimensional geriatric assessment in elderly cancer patients
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Age, sex and gender impact multidimensional geriatric assessment in elderly cancer patients

机译：老年癌症患者的年龄，性别和性别影响多维老年医学评估

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Objectives: Multidimensional geriatric assessment (MGA) is essential in individualized treatment decisions in the elderly. The goal of this pilot study was to analyze the impact of age, sex and possibly gender on assessment status in senior cancer patients. Materials and methods: An MGA consisting of 12 scores was applied in 111 patients (range 60-99, median 75. years; 51% female). The effect of sex on individual MGA test results was evaluated by analysis of covariance adjusting for the confounding effect of age. The effect of age was investigated by partial correlation analysis adjusting for sex. Results: Women were significantly older than men (men 76.6 vs. 72.2. years, p. =0.008), and advanced age was weakly associated with a reduced assessment status in most MGA dimensions. Age as a confounding factor was apparent in WHO performance status and in the "Timed Up and Go Test"; women's weaker performance status disappeared when adjusted for age. A significant effect of sex was observed in iADL (better functional activities in women), F-SozU (less perceived social support in women), BMI (lower BMI in women) and comorbidities (fewer comorbidities in women). The sex differences in iADL disappeared completely after omitting the gender-specific items in the iADL-5, thus implying a pronounced gender effect. Likewise, the significant difference in self-perceived emotional support (F-SozU 4.3 women vs. 4.6 men, p. =0.005) suggests a gender effect in this dimension. Conclusion: Age, sex and gender need to be recognized and integrated as interplaying and confounding factors in the assessment of elderly cancer patients.
机译：目的：多维老年人评估（MGA）对于老年人的个性化治疗决策至关重要。这项初步研究的目的是分析年龄，性别以及可能的性别对老年癌症患者评估状态的影响。材料和方法：对111位患者（范围60-99，中位75.岁;女性51％）应用了包含12个评分的MGA。通过对年龄的混杂影响进行协方差分析来评估性别对单个MGA测试结果的影响。通过对性别进行偏相关分析，研究了年龄的影响。结果：女性明显比男性大（男性76.6比72.2。岁，p = 0.008），并且在大多数MGA维度中，高龄与评估状态的降低弱相关。在世界卫生组织的绩效状况和“定时上岗测试”中，年龄是一个令人困惑的因素。调整年龄后，女性较弱的表现状态消失了。在iADL（妇女的功能更好的活动），F-SozU（妇女的社会支持较少），BMI（妇女的BMI较低）和合并症（妇女的合并症较少）中观察到性的显着影响。省略了iADL-5中的性别特定项后，iADL中的性别差异完全消失，这意味着明显的性别效应。同样，自我感知的情感支持上的显着差异（F-SozU 4.3女性和4.6男性，p = 0.005）表明了这一方面的性别效应。结论：年龄，性别和性别是老年癌症患者评估中相互作用和混淆的因素，必须予以认识和综合。

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