Do elderly patients benefit from enrollment into Phase I Trials?

Tai Wai Meng; Lim Cindy; Ahmad Aziah; Ong Whee Sze; Choo Su Pin; Lim Wan Teck; Tan Eng Huat; Kanesvaran Ravindran; Tan Daniel Shao Weng

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Do elderly patients benefit from enrollment into Phase I Trials?

机译：老年患者是否可以从参加第一阶段试验中受益？

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Background: Despite the significant burden of cancer in the older population, their outcomes in the context of phase I studies have been poorly studied. While the Royal Marsden Hospital (RMH) prognostic score (albumin, lactate dehydrogenase [LDH], number of metastatic sites) is validated in this setting, its utility among the elderly is uncertain.

机译：背景：尽管在老年人口中癌症负担很重，但在第一阶段研究的背景下对他们的结局研究却很少。尽管在这种情况下可以验证皇家马斯登医院（RMH）的预后评分（白蛋白，乳酸脱氢酶[LDH]，转移部位的数量），但其在老年人中的效用尚不确定。

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来源
《Journal of geriatric oncology》 |2015年第3期|共8页
作者
Tai Wai Meng; Lim Cindy; Ahmad Aziah; Ong Whee Sze; Choo Su Pin; Lim Wan Teck; Tan Eng Huat; Kanesvaran Ravindran; Tan Daniel Shao Weng;
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正文语种 eng
中图分类肿瘤学;
关键词
Phase I; Oncology clinical trials; Elderly;

机译：一期;肿瘤临床试验;老年人;

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专利

1. Do elderly patients benefit from enrollment into Phase I Trials? [J] . Tai Wai Meng, Lim Cindy, Ahmad Aziah, Journal of geriatric oncology . 2015,第3期

机译：老年患者是否可以从参加第一阶段试验中受益？
2. Feasibility and Benefit of Molecularly-Informed Enrollment into Early Phase Clinical Trials for Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma [J] . Michot Jean-Marie, Camara-Clayette Valerie, Detolle Audrey, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：分子信息的可行性和益处，对复发或难治性弥漫性大B细胞淋巴瘤患者的早期临床试验
3. Elderly patients benefit from second-line cytotoxic chemotherapy: a subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer. [J] . Weiss GJ, Langer C, Rosell R, Journal of Clinical Oncology . 2006,第27期

机译：老年患者受益于二线细胞毒性化疗：对先前接受治疗的晚期非小细胞肺癌患者进行培美曲塞与多西他赛比较的一项随机III期临床试验的亚组分析。
4. Clinical Benefit of an Adsorptive Technique for Elderly Long-Term Hemodialysis Patients [C] . Takahiro Kuragano, Arithoshi Kida, ManaYahiro, Nihon To?seki Igakkai., Gakujutsu Shu?kai So?kai . 2019

机译：老年长期血液透析患者吸附技术的临床益处
5. Communication preferences, expectations of benefit, and symptom burdens among advanced cancer patients and partners during patient participation in phase I trials [D] . Hlubocky, Fay J. 2010

机译：患者参加I期试验期间，晚期癌症患者及其伴侣之间的沟通偏好，受益期望以及症状负担
6. OS4.3 Feasibility and benefit of Molecular Profiling to Guide Enrollment of Patients with Recurrent Gliomas in Early Phase Trials [O] . C Baldini, N Younan, E Castanon Alvarez, 2019

机译：OS4.3分子分析的可行性和益处以指导早期试验中复发性胶质瘤患者的患者
7. Barriers to Enrollment of Elderly Adults in Early-Phase Cancer Clinical Trials [O] . Basche, Michele, Barón, Anna E., Eckhardt, S. Gail, 2008

机译：早期癌症临床试验中老年人入选的障碍

Do elderly patients benefit from enrollment into Phase I Trials?

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