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首页> 外文期刊>Clinical rheumatology >Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis
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Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis

机译：年轻参与者的膝部肌肉力量与关节软骨T2放松时间相关，并具有骨关节炎的危险因素

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The objective of this study is to correlate T2 relaxation time (T2RT), measured by magnetic resonance imaging (MRI) with quadriceps and hamstring strength in young participants with risk factors for knee osteoarthritis (OA). A descriptive cross-sectional study was conducted with participants between 20 and 40 years of age, without diagnosis of knee OA. Their T2 relaxation time was measured through MRI, and their muscle strength (MS) was measured with an isokinetic dynamometer. Seventy-one participants were recruited, with an average age of 28.3 +/- 5.5 years; 39 (55 %) were females. Negative correlations were found between T2RT and quadriceps peak torque (QPT) in males in the femur r = -0.46 (p = 0.01), tibia r = -0.49 (p = 0.02), and patella r = -0.44 (p = 0.01). In women, correlations were found among the femur r = -0.43 (p = 0.01), tibia r = -0.61 (p = 0.01), and patella r = -0.32 (p = 0.05) and among hamstring peak torque (HPT), in the femur r = -0.46 (p = 0.01), hamstring total work (HTW) r = -0.42 (p = 0.03), and tibia r = -0.33 (p = 0.04). Linear regression models showed good capacity to predict T2RT through QPT in both genders. The present study shows that early changes in femoral, tibial, and patellar cartilage are significantly correlated with MS, mainly QPT, and that these early changes might be explained by MS, which could play an important role in pre-clinical phases of the disease.
机译：这项研究的目的是将年轻参与者的股四头肌和绳肌力量与通过磁共振成像（MRI）测量的T2放松时间（T2RT）与膝骨关节炎（OA）的危险因素相关联。一项描述性横断面研究是针对20至40岁的参与者进行的，没有诊断出膝关节炎。通过MRI测量其T2弛豫时间，并使用等速测功机测量其肌肉强度（MS）。招募了71名参与者，平均年龄为28.3 +/- 5.5岁; 39（55％）是女性。男性股骨的T2RT与股四头肌峰值扭矩（QPT）之间存在负相关性r = -0.46（p = 0.01），胫骨r = -0.49（p = 0.02）和骨r = -0.44（p = 0.01） 。在女性中，股骨r = -0.43（p = 0.01），胫骨r = -0.61（p = 0.01）和骨r = -0.32（p = 0.05）与绳肌峰值扭矩（HPT）之间存在相关性，在股骨中r = -0.46（p = 0.01），绳肌总功（HTW）r = -0.42（p = 0.03），胫骨r = -0.33（p = 0.04）。线性回归模型显示了通过QPT预测男女T2RT的良好能力。本研究表明，股骨，胫骨和pa骨软骨的早期变化与MS（主要是QPT）显着相关，并且这些早期变化可能由MS解释，这可能在疾病的临床前期中发挥重要作用。

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