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首页> 外文期刊>Clinical pharmacokinetics >Pharmacokinetic and pharmacodynamic parameters of antimicrobials: Potential for providing dosing regimens that are less vulnerable to resistance
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Pharmacokinetic and pharmacodynamic parameters of antimicrobials: Potential for providing dosing regimens that are less vulnerable to resistance

机译：抗菌药物的药代动力学和药效学参数：提供不易产生耐药性的给药方案的潜力

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摘要

Whereas infections caused by multidrug-resistant micro-organisms are increasing worldwide, there are few new molecules, especially ones that are active against Gram-negative strains. There are extensive data showing that the administration of antimicrobials according to pharmacokinetic/pharmacodynamic parameters improves the possibility of a positive clinical outcome, particularly in severely ill patients. Evidence is growing that when pharmacokinetic/ pharmacodynamic parameters are used to target not only clinical cure but also eradication, the spread of resistance will also be contained. The present paper summarizes the most relevant papers published in this field and provides some suggestions for dosing regimens that can be adopted in the clinical setting to limit the spread of resistance.
机译：在世界范围内，由耐多药微生物引起的感染正在增加，但是很少有新分子出现，尤其是那些对革兰氏阴性菌株有活性的分子。有大量数据表明，根据药代动力学/药效学参数施用抗微生物药可改善临床结果阳性的可能性，特别是在重症患者中。越来越多的证据表明，当将药代动力学/药效学参数不仅用于临床治愈而且用于根除时，耐药性的扩散也将得到遏制。本文总结了该领域中最相关的论文，并为可在临床环境中采用以限制耐药性扩散的给药方案提供了一些建议。

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