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首页> 外文期刊>Journal of glaucoma >Effect of latanoprost on the diurnal variations in the intraocular and ocular perfusion pressure in normal tension glaucoma.
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Effect of latanoprost on the diurnal variations in the intraocular and ocular perfusion pressure in normal tension glaucoma.

机译：拉坦前列素对正常张力性青光眼眼内和眼内灌注压力的昼夜变化的影响。

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摘要

PURPOSE: To evaluate the effects of latanoprost on the diurnal variations in the intraocular pressure (IOP) combined with the ocular perfusion pressure (OPP) in patients with normal tension glaucoma (NTG). PATIENTS AND METHODS: Twenty-two eyes from 22 patients with NTG were used for the study. The diurnal variations in the IOP and blood pressure (BP) were measured every 3 hours without therapy, and then the patients were treated with latanoprost (0.005%) once daily for more than 12 weeks. The diurnal variations in the IOP and BP under medication were again measured every 6 hours. The diurnal variation of IOP for 24 hours, mean diurnal IOP, maximum IOP, minimum IOP, range of variation in IOP, OPP, and BP were compared between the baseline and after treatment by means of a paired t test. RESULTS: At 3 months after the start of the latanoprost treatment regimen, the IOP showed a statistically significant decrease at every assessed time point over 24 hours (P<0.001). Latanoprost significantly reduced the mean diurnal IOP, maximum IOP, minimum IOP, and mean range of variation in the IOP values from baseline (P<0.001, <0.001, <0.001, and 0.009, respectively). OPP after treatment showed no significant difference at any assessed time points from the baseline (P>0.1). Latanoprost did not significantly alter the mean diurnal OPP (P>0.1), and BP (P>0.5) from the baseline. CONCLUSIONS: Latanoprost was thus found to significantly reduce IOP over 24 hours, whereas it does not affect OPP and BP in NTG patients. Therefore, it may be a useful medication for NTG.
机译：目的：评估拉坦前列素对正常张力性青光眼（NTG）患者眼内压（IOP）与眼灌注压（OPP）的昼夜变化的影响。患者与方法：来自22例NTG患者的22只眼用于研究。每3小时测量一次IOP和血压（BP）的昼夜变化，然后不治疗，然后每天用拉坦前列素（0.005％）治疗患者一次，持续12周以上。每6小时再次测量药物治疗下眼压和血压的昼夜变化。在基线和治疗后，通过配对t检验比较24小时眼压的每日变化，平均眼压，最大眼压，最小眼压，眼压，眼压和血压的变化范围。结果：开始拉坦前列素治疗方案后3个月，IOP在24小时内的每个评估时间点均显示出统计学显着性下降（P <0.001）。拉坦前列素显着降低平均每日IOP，最大IOP，最小IOP和IOP值相对于基线的平均变化范围（分别为P <0.001，<0.001，<0.001和0.009）。治疗后的OPP与基线相比在任何评估的时间点均无显着差异（P> 0.1）。拉坦前列素与基线相比没有显着改变平均日均OPP（P> 0.1）和BP（P> 0.5）。结论：因此发现拉坦前列素可在24小时内显着降低IOP，但不影响NTG患者的OPP和BP。因此，它可能是NTG的有用药物。

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